2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {5-[3-amino-1-(3-chloro-phenyl)-propylcarbamoyl]-2-chloro-4-fluoro-phenyl}-amide

Base Information

Chemical Name:2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {5-[3-amino-1-(3-chloro-phenyl)-propylcarbamoyl]-2-chloro-4-fluoro-phenyl}-amide
CAS No.:1386980-34-2
Molecular Formula:C₂₈H₂₆Cl₂FN₇O₄
Molecular Weight:614.463
Hs Code.:

2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {5-[3-amino-1-(3-chloro-phenyl)-propylcarbamoyl]-2-chloro-4-fluoro-phenyl}-amide

Synonyms:2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {5-[3-amino-1-(3-chloro-phenyl)-propylcarbamoyl]-2-chloro-4-fluoro-phenyl}-amide

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Chemical Property of 2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {5-[3-amino-1-(3-chloro-phenyl)-propylcarbamoyl]-2-chloro-4-fluoro-phenyl}-amide

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Technology Process of 2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {5-[3-amino-1-(3-chloro-phenyl)-propylcarbamoyl]-2-chloro-4-fluoro-phenyl}-amide

There total 8 articles about 2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {5-[3-amino-1-(3-chloro-phenyl)-propylcarbamoyl]-2-chloro-4-fluoro-phenyl}-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.3%

: 1386981-55-0
[3-{4-chloro-2-fluoro-5-[(2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoylamino}-3-(3-chloro-phenyl)-propyl]-carbamic acid tert-butyl ester

: 1386980-34-2
2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {5-[3-amino-1-(3-chloro-phenyl)-propylcarbamoyl]-2-chloro-4-fluoro-phenyl}-amide

Guidance literature:: [3-{4-chloro-2-fluoro-5-[(2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoylamino}-3-(3-chloro-phenyl)-propyl]-carbamic acid tert-butyl ester; With trifluoroacetic acid; In dichloromethane; for 2h;

With sodium hydroxide; In water; ethyl acetate;

Reference yield:

: 774-07-2
ethyl 4-amino-2-mercapto-pyrimidine-5-carboxylate

: 1386980-34-2
2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {5-[3-amino-1-(3-chloro-phenyl)-propylcarbamoyl]-2-chloro-4-fluoro-phenyl}-amide

Guidance literature:: Multi-step reaction with 5 steps

1.1: 90 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Cooling with ice

2.2: Cooling with ice

3.1: manganese(IV) oxide / dichloromethane / 24 h / Inert atmosphere

4.1: piperidine / methanol / 4 h / 80 °C / sealed tube

5.1: trifluoroacetic acid / dichloromethane / 2 h

With piperidine; manganese(IV) oxide; lithium aluminium tetrahydride; trifluoroacetic acid; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 21667-62-9
3-chlorobenzoylacetonitrile

: 1386980-34-2
2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carboxylic acid {5-[3-amino-1-(3-chloro-phenyl)-propylcarbamoyl]-2-chloro-4-fluoro-phenyl}-amide

Guidance literature:: Multi-step reaction with 8 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 60 °C / Inert atmosphere

1.2: 0 °C

2.1: tetrahydrofuran / 0.5 h

3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 5 °C

4.1: hydrazine hydrate / tetrahydrofuran; methanol / 2 h / 55 °C

5.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h

5.2: 2 h

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.02 h / Cooling with ice

6.2: 2.08 h / Cooling with ice

7.1: piperidine / methanol / 4 h / 80 °C / sealed tube

8.1: trifluoroacetic acid / dichloromethane / 2 h

With piperidine; lithium aluminium tetrahydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; trifluoroacetic acid; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;