[3-{4-chloro-2-fluoro-5-[(2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoylamino}-3-(3-chloro-phenyl)-propyl]-carbamic acid tert-butyl ester

Base Information

Chemical Name:[3-{4-chloro-2-fluoro-5-[(2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoylamino}-3-(3-chloro-phenyl)-propyl]-carbamic acid tert-butyl ester
CAS No.:1386981-55-0
Molecular Formula:C₃₃H₃₄Cl₂FN₇O₆
Molecular Weight:714.581
Hs Code.:

[3-{4-chloro-2-fluoro-5-[(2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoylamino}-3-(3-chloro-phenyl)-propyl]-carbamic acid tert-butyl ester

Synonyms:[3-{4-chloro-2-fluoro-5-[(2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoylamino}-3-(3-chloro-phenyl)-propyl]-carbamic acid tert-butyl ester

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Chemical Property of [3-{4-chloro-2-fluoro-5-[(2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoylamino}-3-(3-chloro-phenyl)-propyl]-carbamic acid tert-butyl ester

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Technology Process of [3-{4-chloro-2-fluoro-5-[(2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoylamino}-3-(3-chloro-phenyl)-propyl]-carbamic acid tert-butyl ester

There total 7 articles about [3-{4-chloro-2-fluoro-5-[(2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoylamino}-3-(3-chloro-phenyl)-propyl]-carbamic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 56.7%

: 1386981-32-3
4-amino-2-morpholinopyrimidine-5-carbaldehyde

: 1386981-54-9
N-{5-[3-tert-Butoxycarbonylamino-1-(3-chloro-phenyl)-propylcarbamoyl]-2-chloro-4-fluoro-phenyl}-malonamic acid methyl ester

: 1386981-55-0
[3-{4-chloro-2-fluoro-5-[(2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoylamino}-3-(3-chloro-phenyl)-propyl]-carbamic acid tert-butyl ester

Guidance literature:: With piperidine; In methanol; at 80 ℃; for 4h; sealed tube;

Reference yield:

: 774-07-2
ethyl 4-amino-2-mercapto-pyrimidine-5-carboxylate

: 1386981-55-0
[3-{4-chloro-2-fluoro-5-[(2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoylamino}-3-(3-chloro-phenyl)-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: 90 °C / Inert atmosphere

2.1: lithium aluminium tetrahydride / tetrahydrofuran / 20 °C / Cooling with ice

2.2: Cooling with ice

3.1: manganese(IV) oxide / dichloromethane / 24 h / Inert atmosphere

4.1: piperidine / methanol / 4 h / 80 °C / sealed tube

With piperidine; manganese(IV) oxide; lithium aluminium tetrahydride; In tetrahydrofuran; methanol; dichloromethane;

Reference yield:

: 21667-62-9
3-chlorobenzoylacetonitrile

: 1386981-55-0
[3-{4-chloro-2-fluoro-5-[(2-morpholin-4-yl-7-oxo-7,8-dihydro-pyrido[2,3-d]pyrimidine-6-carbonyl)-amino]-benzoylamino}-3-(3-chloro-phenyl)-propyl]-carbamic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 7 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 0 - 60 °C / Inert atmosphere

1.2: 0 °C

2.1: tetrahydrofuran / 0.5 h

3.1: triphenylphosphine; diethylazodicarboxylate / tetrahydrofuran / 1 h / 5 °C

4.1: hydrazine hydrate / tetrahydrofuran; methanol / 2 h / 55 °C

5.1: N-ethyl-N,N-diisopropylamine; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate / N,N-dimethyl-formamide / 0.25 h

5.2: 2 h

6.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 0.02 h / Cooling with ice

6.2: 2.08 h / Cooling with ice

7.1: piperidine / methanol / 4 h / 80 °C / sealed tube

With piperidine; lithium aluminium tetrahydride; O-(1H-benzotriazol-1-yl)-N,N,N',N'-tetramethyluronium hexafluorophosphate; hydrazine hydrate; N-ethyl-N,N-diisopropylamine; triphenylphosphine; diethylazodicarboxylate; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;