(S)-2-({(S)-1-[(S)-3-(Allyl-tert-butoxycarbonyl-amino)-butyryl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid allyl ester

Base Information

Chemical Name:(S)-2-({(S)-1-[(S)-3-(Allyl-tert-butoxycarbonyl-amino)-butyryl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid allyl ester
CAS No.:480440-30-0
Molecular Formula:C₂₉H₄₁N₃O₆
Molecular Weight:527.661
Hs Code.:

Synonyms:(S)-2-({(S)-1-[(S)-3-(Allyl-tert-butoxycarbonyl-amino)-butyryl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid allyl ester

Suppliers and Price of (S)-2-({(S)-1-[(S)-3-(Allyl-tert-butoxycarbonyl-amino)-butyryl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid allyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (S)-2-({(S)-1-[(S)-3-(Allyl-tert-butoxycarbonyl-amino)-butyryl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid allyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (S)-2-({(S)-1-[(S)-3-(Allyl-tert-butoxycarbonyl-amino)-butyryl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid allyl ester

There total 9 articles about (S)-2-({(S)-1-[(S)-3-(Allyl-tert-butoxycarbonyl-amino)-butyryl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid allyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 76.0%

: 107-18-6
allyl alcohol

: (S)-2-({(S)-1-[3-(Allyl-tert-butoxycarbonyl-amino)-butyryl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid

: 480440-30-0
(S)-2-({(S)-1-[(S)-3-(Allyl-tert-butoxycarbonyl-amino)-butyryl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid allyl ester

: 480440-31-1
(S)-2-({(S)-1-[(R)-3-(Allyl-tert-butoxycarbonyl-amino)-butyryl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid allyl ester

Guidance literature:: (S)-2-({(S)-1-[3-(Allyl-tert-butoxycarbonyl-amino)-butyryl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid; With triethylamine; isobutyl chloroformate;

allyl alcohol;
DOI:10.1016/S0040-4039(02)01237-6

Reference yield:

: 480440-27-5
3-(allyl-tert-butoxycarbonyl-amino)-butyric acid

: O-allyl-L-phenylalanine-L-proline

: 480440-30-0
(S)-2-({(S)-1-[(S)-3-(Allyl-tert-butoxycarbonyl-amino)-butyryl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid allyl ester

Guidance literature:: With benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; In dichloromethane; at 0 - 20 ℃;
DOI:10.1016/S0040-4039(02)01237-6

Reference yield:

: 24424-99-5
di-tert-butyl dicarbonate

: 480440-30-0
(S)-2-({(S)-1-[(S)-3-(Allyl-tert-butoxycarbonyl-amino)-butyryl]-pyrrolidine-2-carbonyl}-amino)-3-phenyl-propionic acid allyl ester

Guidance literature:: Multi-step reaction with 3 steps

1.1: Yb(OTf)3 / tetrahydrofuran / 20 °C

1.2: 67 percent / N,N-dimethylaminopyridine / CH₂Cl₂ / 20 °C

2.1: LiOH

3.1: 76 percent / ClCOOiBu; Et₃N

With lithium hydroxide; triethylamine; ytterbium(III) triflate; isobutyl chloroformate; In tetrahydrofuran; 1.1: Michael addition;
DOI:10.1016/S0040-4039(02)01237-6