2-[[(2,3-difluorophenyl)methyl]thio]-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-5-(4-pyridinylthio)-4-pyrimidinol

Base Information

Chemical Name:2-[[(2,3-difluorophenyl)methyl]thio]-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-5-(4-pyridinylthio)-4-pyrimidinol
CAS No.:666752-76-7
Molecular Formula:C₁₉H₁₈F₂N₄O₂S₂
Molecular Weight:436.506
Hs Code.:

Synonyms:2-[[(2,3-difluorophenyl)methyl]thio]-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-5-(4-pyridinylthio)-4-pyrimidinol

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Chemical Property of 2-[[(2,3-difluorophenyl)methyl]thio]-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-5-(4-pyridinylthio)-4-pyrimidinol

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Technology Process of 2-[[(2,3-difluorophenyl)methyl]thio]-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-5-(4-pyridinylthio)-4-pyrimidinol

There total 2 articles about 2-[[(2,3-difluorophenyl)methyl]thio]-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-5-(4-pyridinylthio)-4-pyrimidinol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 4556-23-4
pyridine-4-thiol

: 666752-67-6
2-[[(2,3-difluorophenyl)methyl]thio]-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-4-pyrimidinol

: 666752-76-7
2-[[(2,3-difluorophenyl)methyl]thio]-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-5-(4-pyridinylthio)-4-pyrimidinol

Guidance literature:: With pyridine; bromine; In DMF (N,N-dimethyl-formamide); for 1h;

Reference yield:

: 666752-51-8
6-{[(1R)-2-hydroxy-1-methylethyl]amino}-2-mercapto-4-pyrimidinol

: 666752-76-7
2-[[(2,3-difluorophenyl)methyl]thio]-6-[[(1R)-2-hydroxy-1-methylethyl]amino]-5-(4-pyridinylthio)-4-pyrimidinol

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide / ethanol; water / 1 h

2: pyridine; bromine / DMF (N,N-dimethyl-formamide) / 1 h

With pyridine; sodium hydroxide; bromine; In DMF (N,N-dimethyl-formamide); ethanol; water;