3-(3-(cyclopentyloxy)-4-methoxyphenyl)-5-(4-fluorophenyl)-1,2,4-oxadiazole

Base Information

Chemical Name:3-(3-(cyclopentyloxy)-4-methoxyphenyl)-5-(4-fluorophenyl)-1,2,4-oxadiazole
CAS No.:1163715-94-3
Molecular Formula:C₂₀H₁₉FN₂O₃
Molecular Weight:354.381
Hs Code.:

Synonyms:3-(3-(cyclopentyloxy)-4-methoxyphenyl)-5-(4-fluorophenyl)-1,2,4-oxadiazole

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Chemical Property of 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-5-(4-fluorophenyl)-1,2,4-oxadiazole

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Technology Process of 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-5-(4-fluorophenyl)-1,2,4-oxadiazole

There total 4 articles about 3-(3-(cyclopentyloxy)-4-methoxyphenyl)-5-(4-fluorophenyl)-1,2,4-oxadiazole which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 41.0%

: 456-22-4
4-Fluorobenzoic acid

: 874485-04-8
C₁₃H₁₈N₂O₃

: 1163715-94-3
3-(3-(cyclopentyloxy)-4-methoxyphenyl)-5-(4-fluorophenyl)-1,2,4-oxadiazole

Guidance literature:: 4-Fluorobenzoic acid; With dicyclohexyl-carbodiimide; In N,N-dimethyl-formamide; at 0 ℃; for 1h; Inert atmosphere;

C₁₃H₁₈N₂O₃; In N,N-dimethyl-formamide; at 0 - 110 ℃; for 13.5h; Inert atmosphere;
DOI:10.1111/j.1747-0285.2011.01304.x

Reference yield:

: 159783-16-1
3-(cyclopentyloxy)-4-methoxybenzonitrile

: 1163715-94-3
3-(3-(cyclopentyloxy)-4-methoxyphenyl)-5-(4-fluorophenyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 2 steps

1.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 18 h / 0 °C / Reflux

2.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

2.2: 13.5 h / 0 - 110 °C / Inert atmosphere

With hydroxylamine hydrochloride; dicyclohexyl-carbodiimide; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1111/j.1747-0285.2011.01304.x

Reference yield:

: 621-59-0
isovanillin

: 1163715-94-3
3-(3-(cyclopentyloxy)-4-methoxyphenyl)-5-(4-fluorophenyl)-1,2,4-oxadiazole

Guidance literature:: Multi-step reaction with 4 steps

1.1: formic acid; hydroxylamine hydrochloride; sodium formate / 3 h / 125 °C

2.1: potassium carbonate / N,N-dimethyl-formamide

3.1: hydroxylamine hydrochloride; sodium hydroxide / ethanol; water / 18 h / 0 °C / Reflux

4.1: dicyclohexyl-carbodiimide / N,N-dimethyl-formamide / 1 h / 0 °C / Inert atmosphere

4.2: 13.5 h / 0 - 110 °C / Inert atmosphere

With formic acid; hydroxylamine hydrochloride; sodium formate; potassium carbonate; dicyclohexyl-carbodiimide; sodium hydroxide; In ethanol; water; N,N-dimethyl-formamide;
DOI:10.1111/j.1747-0285.2011.01304.x