(4R,5S)-3-(3-fluoro-4-morpholinophenyl)-5-(hydroxymethyl)-4-(4-methoxyphenyl)oxazolidin-2-one

Base Information

Chemical Name:(4R,5S)-3-(3-fluoro-4-morpholinophenyl)-5-(hydroxymethyl)-4-(4-methoxyphenyl)oxazolidin-2-one
CAS No.:1613057-75-2
Molecular Formula:C₂₁H₂₃FN₂O₅
Molecular Weight:402.422
Hs Code.:

Synonyms:(4R,5S)-3-(3-fluoro-4-morpholinophenyl)-5-(hydroxymethyl)-4-(4-methoxyphenyl)oxazolidin-2-one

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Chemical Property of (4R,5S)-3-(3-fluoro-4-morpholinophenyl)-5-(hydroxymethyl)-4-(4-methoxyphenyl)oxazolidin-2-one

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Technology Process of (4R,5S)-3-(3-fluoro-4-morpholinophenyl)-5-(hydroxymethyl)-4-(4-methoxyphenyl)oxazolidin-2-one

There total 3 articles about (4R,5S)-3-(3-fluoro-4-morpholinophenyl)-5-(hydroxymethyl)-4-(4-methoxyphenyl)oxazolidin-2-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1613057-74-1
(4R,5R)-3-(3-fluoro-4-morpholinophenyl)-4-(4-methoxyphenyl)-5-vinyloxazolidin-2-one

: 1613057-75-2
(4R,5S)-3-(3-fluoro-4-morpholinophenyl)-5-(hydroxymethyl)-4-(4-methoxyphenyl)oxazolidin-2-one

Guidance literature:: (4R,5R)-3-(3-fluoro-4-morpholinophenyl)-4-(4-methoxyphenyl)-5-vinyloxazolidin-2-one; With ozone; In dichloromethane; at -78 ℃; for 0.5h;

With sodium tetrahydroborate; dimethylsulfide; In methanol; dichloromethane; at 0 ℃; for 2h;
DOI:10.1016/j.ejmech.2014.04.062

Reference yield:

: 1250999-09-7
4-(2-fluoro-4-iodophenyl)morpholine

: 1613057-75-2
(4R,5S)-3-(3-fluoro-4-morpholinophenyl)-5-(hydroxymethyl)-4-(4-methoxyphenyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 2 steps

1.1: copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 3 h / 110 °C / Inert atmosphere

2.1: ozone / dichloromethane / 0.5 h / -78 °C

2.2: 2 h / 0 °C

With copper(l) iodide; caesium carbonate; ozone; N,N`-dimethylethylenediamine; In 1,4-dioxane; dichloromethane;
DOI:10.1016/j.ejmech.2014.04.062

Reference yield:

: 93246-53-8
3-fluoro-4-(morpholinyl)aniline

: 1613057-75-2
(4R,5S)-3-(3-fluoro-4-morpholinophenyl)-5-(hydroxymethyl)-4-(4-methoxyphenyl)oxazolidin-2-one

Guidance literature:: Multi-step reaction with 3 steps

1.1: toluene-4-sulfonic acid; sodium nitrite; potassium iodide / acetonitrile; water / 0.17 h / 10 - 15 °C

2.1: copper(l) iodide; caesium carbonate; N,N`-dimethylethylenediamine / 1,4-dioxane / 3 h / 110 °C / Inert atmosphere

3.1: ozone / dichloromethane / 0.5 h / -78 °C

3.2: 2 h / 0 °C

With copper(l) iodide; caesium carbonate; toluene-4-sulfonic acid; ozone; potassium iodide; N,N`-dimethylethylenediamine; sodium nitrite; In 1,4-dioxane; dichloromethane; water; acetonitrile;
DOI:10.1016/j.ejmech.2014.04.062