Technology Process of 4-(2-fluoro-4-iodophenyl)morpholine
There total 7 articles about 4-(2-fluoro-4-iodophenyl)morpholine which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
toluene-4-sulfonic acid; potassium iodide; sodium nitrite;
In
water; acetonitrile;
at 10 - 15 ℃;
for 0.166667h;
DOI:10.1016/j.ejmech.2014.04.062
- Guidance literature:
-
N-(2-fluorophenyl)-morpholine;
With
N-iodo-succinimide; trifluoroacetic acid;
at 23 ℃;
for 14h;
Inert atmosphere;
With
sodium carbonate;
In
water;
at 23 ℃;
DOI:10.1002/anie.201007325
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: bis(1,5-cyclooctadiene)nickel(0); sodium t-butanolate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride / 1,4-dioxane / 3 h / 80 °C / Inert atmosphere
2.1: N-iodo-succinimide; trifluoroacetic acid / 14 h / 23 °C / Inert atmosphere
2.2: 23 °C
With
bis(1,5-cyclooctadiene)nickel(0); N-iodo-succinimide; trifluoroacetic acid; sodium t-butanolate; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride;
In
1,4-dioxane;
DOI:10.1002/anie.201007325
