3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]inden-7-ol

Base Information

Chemical Name:3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]inden-7-ol
CAS No.:374081-64-8
Molecular Formula:C₃₃H₃₀N₄O₅S
Molecular Weight:594.691
Hs Code.:

3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3<i>H</i>-8-thia-1,3,4,6-tetraaza-cyclopenta[<i>a</i>]inden-7-ol

Synonyms:3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]inden-7-ol

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Chemical Property of 3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]inden-7-ol

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Technology Process of 3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]inden-7-ol

There total 20 articles about 3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]inden-7-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.0%

: 122-51-0
orthoformic acid triethyl ester

: 374081-63-7
6-amino-1-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-1H-thieno[2,3-d]imidazole-5-carboxylic acid amide

: 374081-64-8
3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]inden-7-ol

Guidance literature:: With acetic anhydride;
DOI:10.1021/ol0165443

Reference yield: 81.0%

: 122-51-0
orthoformic acid triethyl ester

: 374081-63-7
6-amino-1-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-1H-thieno[2,3-d]imidazole-5-carboxylic acid amide

: 374081-64-8
3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H,6H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]inden-7-one

Guidance literature:: With acetic anhydride; for 3h; Heating;
DOI:10.1021/jo0255476

Reference yield:

: 100-39-0
benzyl bromide

: 374081-64-8
3-(3,4-bis-benzyloxy-5-benzyloxymethyl-tetrahydro-furan-2-yl)-3H-8-thia-1,3,4,6-tetraaza-cyclopenta[a]inden-7-ol

Guidance literature:: Multi-step reaction with 7 steps

1: NaH; Bu₄NI

2: EtMgBr

3: NH₂OH*HCl; NaHCO₃

4: 90 percent / Ac₂O

5: 50 percent / K₂CO₃

6: 90 percent / NaOEt / ethanol

7: 82 percent / Ac₂O

With ethylmagnesium bromide; hydroxylamine hydrochloride; sodium ethanolate; acetic anhydride; tetra-(n-butyl)ammonium iodide; sodium hydride; sodium hydrogencarbonate; potassium carbonate; In ethanol;
DOI:10.1021/ol0165443