3-(4-(3-(4-cyano-2-fluoro-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)phenoxy)-N-methylpropanamide

Base Information

Chemical Name:3-(4-(3-(4-cyano-2-fluoro-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)phenoxy)-N-methylpropanamide
CAS No.:1398045-23-2
Molecular Formula:C₂₃H₂₀F₄N₄O₃S
Molecular Weight:508.496
Hs Code.:

Synonyms:3-(4-(3-(4-cyano-2-fluoro-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)phenoxy)-N-methylpropanamide

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Chemical Property of 3-(4-(3-(4-cyano-2-fluoro-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)phenoxy)-N-methylpropanamide

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Technology Process of 3-(4-(3-(4-cyano-2-fluoro-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)phenoxy)-N-methylpropanamide

There total 5 articles about 3-(4-(3-(4-cyano-2-fluoro-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)phenoxy)-N-methylpropanamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 43.0%

: 1311158-94-7
C₉H₂F₄N₂S

: 1398047-02-3
3-(4-((2-cyanopropan-2-yl)amino)phenoxy)-N-methylpropanamide

: 1398045-23-2
3-(4-(3-(4-cyano-2-fluoro-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)phenoxy)-N-methylpropanamide

Guidance literature:: C₉H₂F₄N₂S; 3-(4-((2-cyanopropan-2-yl)amino)phenoxy)-N-methylpropanamide; In N,N-dimethyl-formamide; at 20 ℃;

With hydrogenchloride; methanol; In N,N-dimethyl-formamide; for 2h; Reflux;

Reference yield:

: 10572-16-4
3-(4-nitrophenoxy)propanoic acid

: 1398045-23-2
3-(4-(3-(4-cyano-2-fluoro-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)phenoxy)-N-methylpropanamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: thionyl chloride / 1 h / 40 °C / Reflux

1.2: 1 h / 0 - 20 °C

2.1: hydrogen / palladium on activated charcoal / 1.5 h / 20 °C / Reflux

2.2: 1 h / 0 - 20 °C

3.1: iodine / 0.5 h / 20 - 40 °C

4.1: N,N-dimethyl-formamide / 20 °C

4.2: 2 h / Reflux

With thionyl chloride; hydrogen; palladium on activated charcoal; iodine; In N,N-dimethyl-formamide;

Reference yield:

: 100-02-7,78813-13-5,89830-32-0
4-nitro-phenol

: 1398045-23-2
3-(4-(3-(4-cyano-2-fluoro-3-(trifluoromethyl)phenyl)-5,5-dimethyl-4-oxo-2-thioxoimidazolidin-1-yl)phenoxy)-N-methylpropanamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium hydroxide / ethanol; water / 3 h / Reflux

1.2: pH 1

2.1: thionyl chloride / 1 h / 40 °C / Reflux

2.2: 1 h / 0 - 20 °C

3.1: hydrogen / palladium on activated charcoal / 1.5 h / 20 °C / Reflux

3.2: 1 h / 0 - 20 °C

4.1: iodine / 0.5 h / 20 - 40 °C

5.1: N,N-dimethyl-formamide / 20 °C

5.2: 2 h / Reflux

With thionyl chloride; hydrogen; potassium hydroxide; palladium on activated charcoal; iodine; In ethanol; water; N,N-dimethyl-formamide;