4-[1,1-Dimethyl-2-(4-nitro-phenoxy)-ethyl]-1,2-dimethoxy-benzene

Base Information

• Chemical Name: 4-[1,1-Dimethyl-2-(4-nitro-phenoxy)-ethyl]-1,2-dimethoxy-benzene
• CAS No.: 85002-57-9
• Molecular Formula: C₁₈H₂₁NO₅
• Molecular Weight: 331.368
• Mol file: 85002-57-9.mol

Synonyms:4-[1,1-Dimethyl-2-(4-nitro-phenoxy)-ethyl]-1,2-dimethoxy-benzene

Chemical Property of 4-[1,1-Dimethyl-2-(4-nitro-phenoxy)-ethyl]-1,2-dimethoxy-benzene

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 4-[1,1-Dimethyl-2-(4-nitro-phenoxy)-ethyl]-1,2-dimethoxy-benzene

There total 1 articles about 4-[1,1-Dimethyl-2-(4-nitro-phenoxy)-ethyl]-1,2-dimethoxy-benzene which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.4%

2-(3,4-dimethoxy-phenyl)-2-methyl-propan-1-ol (70822-01-4) + 4-chlorobenzonitrile (100-00-5) → 4-[1,1-Dimethyl-2-(4-nitro-phenoxy)-ethyl]-1,2-dimethoxy-benzene (85002-57-9)

Guidance literature:

With sodium hydride; In dimethyl sulfoxide; at 70 ℃; for 0.5h;

DOI:10.1248/cpb.30.3580

Reference yield:

4-[1,1-Dimethyl-2-(4-nitro-phenoxy)-ethyl]-1,2-dimethoxy-benzene (85002-57-9) → 4-[2-(3,4-Dimethoxy-phenyl)-2-methyl-propoxy]-phenylamine

Guidance literature:

With hydrogen; palladium on activated charcoal; In methanol; under 760 Torr; Ambient temperature;

DOI:10.1248/cpb.30.3580

Reference yield:

4-[1,1-Dimethyl-2-(4-nitro-phenoxy)-ethyl]-1,2-dimethoxy-benzene (85002-57-9) → 5-{4-[2-(3,4-Dimethoxy-phenyl)-2-methyl-propoxy]-benzyl}-thiazolidine-2,4-dione (74773-13-0)

Guidance literature:

Multi-step reaction with 3 steps

1: hydrogen / 10percent Pd-C / methanol / 760 Torr / Ambient temperature

2: 1.) NaNO₂, conc. HCl, 2.) Cu₂O / 1.) acetone, water, 5 deg C, 30 min, 2.) acetone, water, 35 deg C

3: 2.) 2N HCl / 1.) sulfolane, 120 deg C, 10 h; 2.) sulfolane, 100 deg C, 8 h

With copper(I) oxide; hydrogenchloride; hydrogen; sodium nitrite; palladium on activated charcoal; In methanol;

DOI:10.1248/cpb.30.3580

upstream raw materials:

2-(3,4-dimethoxy-phenyl)-2-methyl-propan-1-ol

4-chlorobenzonitrile

Downstream raw materials:

2-Chloro-3-{4-[2-(3,4-dimethoxy-phenyl)-2-methyl-propoxy]-phenyl}-propionic acid methyl ester

5-{4-[2-(3,4-Dimethoxy-phenyl)-2-methyl-propoxy]-benzyl}-thiazolidine-2,4-dione