(3S,6R)-1-[6-chloro-2-(methylamino)-4-pyrimidinyl]-6-methyl-N-phenyl-3-piperidinecarboxamide

Base Information

Chemical Name:(3S,6R)-1-[6-chloro-2-(methylamino)-4-pyrimidinyl]-6-methyl-N-phenyl-3-piperidinecarboxamide
CAS No.:1227911-37-6
Molecular Formula:C₁₈H₂₂ClN₅O
Molecular Weight:359.859
Hs Code.:

Synonyms:(3S,6R)-1-[6-chloro-2-(methylamino)-4-pyrimidinyl]-6-methyl-N-phenyl-3-piperidinecarboxamide

Suppliers and Price of (3S,6R)-1-[6-chloro-2-(methylamino)-4-pyrimidinyl]-6-methyl-N-phenyl-3-piperidinecarboxamide

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of (3S,6R)-1-[6-chloro-2-(methylamino)-4-pyrimidinyl]-6-methyl-N-phenyl-3-piperidinecarboxamide

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of (3S,6R)-1-[6-chloro-2-(methylamino)-4-pyrimidinyl]-6-methyl-N-phenyl-3-piperidinecarboxamide

There total 6 articles about (3S,6R)-1-[6-chloro-2-(methylamino)-4-pyrimidinyl]-6-methyl-N-phenyl-3-piperidinecarboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1227911-36-5
(3S,6R)-1-[6-chloro-2-(methylamino)-4-pyrimidinyl]-6-methyl-3-piperidinecarboxylic acid

: 62-53-3
aniline

: 1227911-37-6
(3S,6R)-1-[6-chloro-2-(methylamino)-4-pyrimidinyl]-6-methyl-N-phenyl-3-piperidinecarboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; for 0.75h; Cooling with ice;

Reference yield:

: 5470-70-2
Methyl 6-methylnicotinate

: 1227911-37-6
(3S,6R)-1-[6-chloro-2-(methylamino)-4-pyrimidinyl]-6-methyl-N-phenyl-3-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: hydrogenchloride; platinum(IV) oxide; hydrogen / methanol; water / 4.5 h / 20 °C / 3102.97 Torr

1.2: 15 - 25 °C

2.1: palladium 10% on activated carbon; hydrogen / ethanol; ethyl acetate / 20 °C / 3361.55 Torr

3.1: water; isopropyl alcohol / 60 °C

4.1: lithium hydroxide monohydrate / water / 20 h / 20 °C

4.2: 24 h / 100 °C

4.3: pH 3

5.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0.75 h / 0 °C

With hydrogenchloride; platinum(IV) oxide; lithium hydroxide monohydrate; palladium 10% on activated carbon; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; In methanol; ethanol; dichloromethane; water; ethyl acetate; isopropyl alcohol;
DOI:10.1021/jm101527u

Reference yield:

: 10397-15-6
4,6-dichloro-N-methyl-2-pyrimidinamine

: 1227911-37-6
(3S,6R)-1-[6-chloro-2-(methylamino)-4-pyrimidinyl]-6-methyl-N-phenyl-3-piperidinecarboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: lithium hydroxide monohydrate / water / 20 h / 20 °C

1.2: 24 h / 100 °C

1.3: pH 3

2.1: N-ethyl-N,N-diisopropylamine; HATU / dichloromethane / 0.75 h / 0 °C

With lithium hydroxide monohydrate; N-ethyl-N,N-diisopropylamine; HATU; In dichloromethane; water;
DOI:10.1021/jm101527u