4,6-Dichloro-n-methylpyrimidin-2-amine

Base Information

• Chemical Name: 4,6-Dichloro-n-methylpyrimidin-2-amine
• CAS No.: 10397-15-6
• Molecular Formula: C5H5 Cl2 N3
• Molecular Weight: 178.021
• Hs Code.: 2933599090
• NSC Number: 90604
• DSSTox Substance ID: DTXSID10293547
• Wikidata: Q82032347
• Mol file: 10397-15-6.mol

Synonyms:4,6-dichloro-n-methylpyrimidin-2-amine;10397-15-6;2,6-dichloro-N-Methyl pyriMidin-4-aMine;NSC90604;NCIOpen2_001446;2-PYRIMIDINAMINE, 4,6-DICHLORO-N-METHYL-;SCHEMBL1318655;DTXSID10293547;UBGCYDBGKBKRCT-UHFFFAOYSA-N;CS-M1588;MFCD02091109;NSC-90604;2-methylamino-4,6-dichloro-pyrimidine;AKOS016008726;MB02225;4,6-dichloro-N-methyl-2-pyrimidinamine;(4,6-dichlorpyrimidin-2-yl)-methylamine;2-Pyrimidinamine,4,6-dichloro-N-methyl-;CS-17068;(4,6-dichloro-pyrimidin-2-yl)-methylamine;FT-0686193;EN300-655523;N-(4,6-dichloro-pyrimidin-2-yl)-methyl-amine;Y10236;J-514145

Chemical Property of 4,6-Dichloro-n-methylpyrimidin-2-amine

Chemical Property:

• Vapor Pressure: 0.0015mmHg at 25°C
• Melting Point: 164 °C
• Refractive Index: 1.619
• Boiling Point: 295.7°C at 760 mmHg
• PKA: 0.45±0.25(Predicted)
• Flash Point: 132.7°C
• PSA: 37.81000
• Density: 1.492g/cm³
• LogP: 1.89810
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 2.4
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 1
• Exact Mass: 176.9860526
• Heavy Atom Count: 10
• Complexity: 101

Purity/Quality:

97% ^*data from raw suppliers

4,6-Dichloro-N-methylpyrimidin-2-amine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CNC1=NC(=CC(=N1)Cl)Cl

Technology Process of 4,6-Dichloro-n-methylpyrimidin-2-amine

There total 6 articles about 4,6-Dichloro-n-methylpyrimidin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

→ 4,6-dichloro-N-methyl-2-pyrimidinamine (10397-15-6)

Guidance literature:

Reference yield: 60.0%

2,4,6-trichloropyrimidine (3764-01-0) + methylamine (74-89-5) → 4,6-dichloro-N-methyl-2-pyrimidinamine (10397-15-6) + (2,6-dichloro-pyrimidin-4-yl)-methyl-amine (32998-03-1)

Guidance literature:

In ethanol; for 1h; Ambient temperature;

DOI:10.1080/15257779408009479

Reference yield:

methylamine (74-89-5) + 4,6-dichloro-2-(methylsulfonyl)pyrimidine (4489-34-3) → 4,6-dichloro-N-methyl-2-pyrimidinamine (10397-15-6)

Guidance literature:

In ethyl acetate; at 5 - 20 ℃; for 1.41667h;

upstream raw materials:

2,4,6-trichloropyrimidine

ethanol

methylamine

2-methylamino-1H-pyrimidine-4,6-dione

Downstream raw materials:

(2S,5R)-4-[6-(3-amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-5-methyl-2-morpholinecarboxamide

(3S,6R)-1-[6-chloro-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide

GKS2334470

(3S,6R)-1-[6-chloro-2-(methylamino)-4-pyrimidinyl]-6-methyl-N-phenyl-3-piperidinecarboxamide