di-tert-butyl 5-bromo-2-hydroxyphenylphosphonate

Base Information

• Chemical Name: di-tert-butyl 5-bromo-2-hydroxyphenylphosphonate
• CAS No.: 137360-77-1
• Molecular Formula: C₁₄H₂₂BrO₄P
• Molecular Weight: 365.204
• Mol file: 137360-77-1.mol

Synonyms:di-tert-butyl 5-bromo-2-hydroxyphenylphosphonate

Chemical Property of di-tert-butyl 5-bromo-2-hydroxyphenylphosphonate

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

Useful:

Technology Process of di-tert-butyl 5-bromo-2-hydroxyphenylphosphonate

There total 2 articles about di-tert-butyl 5-bromo-2-hydroxyphenylphosphonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

Phosphoric acid di-tert-butyl ester 2,4-dibromo-phenyl ester (137360-74-8) → di-tert-butyl 5-bromo-2-hydroxyphenylphosphonate (137360-77-1)

Guidance literature:

With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.333333h;

DOI:10.1055/s-1991-26546

Reference yield:

phosphorus oxychloride di-tert-butyl ester (56119-60-9) → di-tert-butyl 5-bromo-2-hydroxyphenylphosphonate (137360-77-1)

Guidance literature:

Multi-step reaction with 2 steps

1: 1) NaH / 1) THF, 0 deg C, 5 min, 2) THF, 0 deg C, 72 h

2: 53 percent / BuLi / tetrahydrofuran; hexane / 0.33 h / -78 °C

With n-butyllithium; sodium hydride; In tetrahydrofuran; hexane;

DOI:10.1055/s-1991-26546

upstream raw materials:

Phosphoric acid di-tert-butyl ester 2,4-dibromo-phenyl ester

phosphorus oxychloride di-tert-butyl ester

Refernces