(2S)-{1-[2-(3-[1,3]dioxolan-2-yl-pyridin-2-yl)-4,5-dimethoxy-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester

Base Information

Chemical Name:(2S)-{1-[2-(3-[1,3]dioxolan-2-yl-pyridin-2-yl)-4,5-dimethoxy-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester
CAS No.:1542227-75-7
Molecular Formula:C₃₃H₃₃N₃O₇
Molecular Weight:583.641
Hs Code.:

Synonyms:(2S)-{1-[2-(3-[1,3]dioxolan-2-yl-pyridin-2-yl)-4,5-dimethoxy-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester

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Chemical Property of (2S)-{1-[2-(3-[1,3]dioxolan-2-yl-pyridin-2-yl)-4,5-dimethoxy-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester

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Technology Process of (2S)-{1-[2-(3-[1,3]dioxolan-2-yl-pyridin-2-yl)-4,5-dimethoxy-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester

There total 9 articles about (2S)-{1-[2-(3-[1,3]dioxolan-2-yl-pyridin-2-yl)-4,5-dimethoxy-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1161-13-3
N-Cbz-L-Phe

: 1542227-73-5
2-(3-[1,3]dioxolan-2-yl-pyridin-2-yl)-4,5-dimethoxy-phenylamine

: 1542227-75-7
(2S)-{1-[2-(3-[1,3]dioxolan-2-yl-pyridin-2-yl)-4,5-dimethoxy-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester

Guidance literature:: With 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 0.166667h;
DOI:10.1080/00397911.2013.771403

Reference yield:

: 1542227-70-2
C₂₀H₃₅NO₄Sn

: 1542227-75-7
(2S)-{1-[2-(3-[1,3]dioxolan-2-yl-pyridin-2-yl)-4,5-dimethoxy-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: tetrakis(triphenylphosphine) palladium⁽⁰⁾; copper(l) iodide; lithium iodide / toluene / 7 h / Inert atmosphere; Reflux

2: toluene-4-sulfonic acid / benzene / 4 h / Inert atmosphere; Molecular sieve; Reflux

3: hydrogen; O₂Pt*3H₂O / ethanol / 760.05 Torr

4: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h / 20 °C

With copper(l) iodide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; O₂Pt*3H₂O; hydrogen; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; lithium iodide; In ethanol; dichloromethane; toluene; benzene;
DOI:10.1080/00397911.2013.771403

Reference yield:

: 1542227-71-3
2-(4,5-dimethoxy-2-nitro-phenyl)-pyridine-3-carbaldehyde

: 1542227-75-7
(2S)-{1-[2-(3-[1,3]dioxolan-2-yl-pyridin-2-yl)-4,5-dimethoxy-phenylcarbamoyl]-2-phenyl-ethyl}-carbamic acid benzyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: toluene-4-sulfonic acid / benzene / 4 h / Inert atmosphere; Molecular sieve; Reflux

2: hydrogen; O₂Pt*3H₂O / ethanol / 760.05 Torr

3: 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0.17 h / 20 °C

With O₂Pt*3H₂O; hydrogen; toluene-4-sulfonic acid; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In ethanol; dichloromethane; benzene;
DOI:10.1080/00397911.2013.771403