4-(5-{5-[(3-chlorophenyl)methylsulfonyl]-2-oxodihydroindol-3-ylidenemethyl}-2,4-dimethyl-1H-pyrrole-3-carbonyl)piperazine-1-carboxylic acid tert-butyl ester

Base Information

• Chemical Name: 4-(5-{5-[(3-chlorophenyl)methylsulfonyl]-2-oxodihydroindol-3-ylidenemethyl}-2,4-dimethyl-1H-pyrrole-3-carbonyl)piperazine-1-carboxylic acid tert-butyl ester
• CAS No.: 1202780-13-9
• Molecular Formula: C₃₂H₃₆ClN₅O₆S
• Molecular Weight: 654.187

Synonyms:4-(5-{5-[(3-chlorophenyl)methylsulfonyl]-2-oxodihydroindol-3-ylidenemethyl}-2,4-dimethyl-1H-pyrrole-3-carbonyl)piperazine-1-carboxylic acid tert-butyl ester

Chemical Property of 4-(5-{5-[(3-chlorophenyl)methylsulfonyl]-2-oxodihydroindol-3-ylidenemethyl}-2,4-dimethyl-1H-pyrrole-3-carbonyl)piperazine-1-carboxylic acid tert-butyl ester

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Technology Process of 4-(5-{5-[(3-chlorophenyl)methylsulfonyl]-2-oxodihydroindol-3-ylidenemethyl}-2,4-dimethyl-1H-pyrrole-3-carbonyl)piperazine-1-carboxylic acid tert-butyl ester

There total 1 articles about 4-(5-{5-[(3-chlorophenyl)methylsulfonyl]-2-oxodihydroindol-3-ylidenemethyl}-2,4-dimethyl-1H-pyrrole-3-carbonyl)piperazine-1-carboxylic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

2-Oxo-2,3-dihydro-1H-indole-5-sulfonic acid (3-chloro-phenyl)-methyl-amide (380241-76-9) + 4-(5-formyl-2,4-dimethyl-1H-pyrrole-3-carbonyl)piperazine-1-carboxylic acid tert-butyl ester (1202780-12-8) → 4-(5-{5-[(3-chlorophenyl)methylsulfonyl]-2-oxodihydroindol-3-ylidenemethyl}-2,4-dimethyl-1H-pyrrole-3-carbonyl)piperazine-1-carboxylic acid tert-butyl ester (1202780-13-9)

Guidance literature:

With pyrrolidine; In ethanol; at 90 ℃; for 5h;

DOI:10.1021/jm900803q

Reference yield: 74.0%

4-(5-{5-[(3-chlorophenyl)methylsulfonyl]-2-oxodihydroindol-3-ylidenemethyl}-2,4-dimethyl-1H-pyrrole-3-carbonyl)piperazine-1-carboxylic acid tert-butyl ester (1202780-13-9) → 3-[3,5-dimethyl-4-(piperazine-1-carbonyl)-1H-pyrrol-2-ylmethylene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid (3-chlorophenyl)methylamide hydrochloride (1202780-14-0)

Guidance literature:

With hydrogenchloride; In ethyl acetate; at 20 ℃; Cooling with ice;

DOI:10.1021/jm900803q

upstream raw materials:

2-Oxo-2,3-dihydro-1H-indole-5-sulfonic acid (3-chloro-phenyl)-methyl-amide

4-(5-formyl-2,4-dimethyl-1H-pyrrole-3-carbonyl)piperazine-1-carboxylic acid tert-butyl ester

Downstream raw materials:

3-[3,5-dimethyl-4-(piperazine-1-carbonyl)-1H-pyrrol-2-ylmethylene]-2-oxo-2,3-dihydro-1H-indole-5-sulfonic acid (3-chlorophenyl)methylamide hydrochloride

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