(S)-Pyrrolidine-1,2-dicarboxylic acid 2-[4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl] ester 1-(9H-fluoren-9-ylmethyl) ester

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Chemical Name:(S)-Pyrrolidine-1,2-dicarboxylic acid 2-[4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl] ester 1-(9H-fluoren-9-ylmethyl) ester
CAS No.:126771-49-1
Molecular Formula:C₃₅H₂₉Cl₂NO₇
Molecular Weight:646.524
Hs Code.:

Synonyms:(S)-Pyrrolidine-1,2-dicarboxylic acid 2-[4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl] ester 1-(9H-fluoren-9-ylmethyl) ester

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Chemical Property of (S)-Pyrrolidine-1,2-dicarboxylic acid 2-[4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl] ester 1-(9H-fluoren-9-ylmethyl) ester

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Technology Process of (S)-Pyrrolidine-1,2-dicarboxylic acid 2-[4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl] ester 1-(9H-fluoren-9-ylmethyl) ester

There total 3 articles about (S)-Pyrrolidine-1,2-dicarboxylic acid 2-[4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl] ester 1-(9H-fluoren-9-ylmethyl) ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 74.0%

: 71989-31-6
Fmoc-Pro-OH

: 126771-40-2
2,4-dichlorophenyl-4-bromomethyl-phenoxyacetate

: 126771-49-1
(S)-Pyrrolidine-1,2-dicarboxylic acid 2-[4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl] ester 1-(9H-fluoren-9-ylmethyl) ester

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In N,N-dimethyl-formamide; for 3h; Ambient temperature;
DOI:10.1016/S0040-4039(00)99355-9

Reference yield:

: 940-64-7
2-(4-methylphenoxy)acetic acid

: 126771-49-1
(S)-Pyrrolidine-1,2-dicarboxylic acid 2-[4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl] ester 1-(9H-fluoren-9-ylmethyl) ester

Guidance literature:: Multi-step reaction with 3 steps

1: 55 percent / N-bromosuccinimide, 2,2'-azobisisobutyronitrile / CHCl₃ / Heating

2: 85 percent / dicyclohexylcarbodiimide / ethyl acetate / 0 °C

3: 74 percent / diisopropylethylamine / dimethylformamide / 3 h / Ambient temperature

With N-Bromosuccinimide; 2,2'-azobis(isobutyronitrile); N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In chloroform; ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)99355-9

Reference yield:

: 126771-41-3
4-bromomethylphenoxyacetic acid

: 126771-49-1
(S)-Pyrrolidine-1,2-dicarboxylic acid 2-[4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl] ester 1-(9H-fluoren-9-ylmethyl) ester

Guidance literature:: Multi-step reaction with 2 steps

1: 85 percent / dicyclohexylcarbodiimide / ethyl acetate / 0 °C

2: 74 percent / diisopropylethylamine / dimethylformamide / 3 h / Ambient temperature

With N-ethyl-N,N-diisopropylamine; dicyclohexyl-carbodiimide; In ethyl acetate; N,N-dimethyl-formamide;
DOI:10.1016/S0040-4039(00)99355-9