126771-40-2

Upstream product

• 126771-41-3 4-bromomethylphenoxyacetic acid 
• 120-83-2 2,4-dichlorophenol 
• 940-64-7 2-(4-methylphenoxy)acetic acid 

Downstream Products

• 126771-43-5 (S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-methyl-butyric acid 4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl ester 
• 126771-51-5 (S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-4-methyl-pentanoic acid 4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl ester 
• 126771-54-8 (S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-propionic acid 4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl ester 
• 126771-50-4 (S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-phenyl-propionic acid 4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl ester 
• 126771-44-6 (S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-pentanedioic acid 5-tert-butyl ester 1-[4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl] ester 
• 126771-47-9 (S)-6-tert-Butoxycarbonylamino-2-(9H-fluoren-9-ylmethoxycarbonylamino)-hexanoic acid 4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl ester 
• 132995-93-8 2,4-dichlorophenyl-4-iodomethyl phenoxy acetate 
• 126771-42-4 (S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-succinamic acid 4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl ester 
• 126771-53-7 (R)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-tritylsulfanyl-propionic acid 4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl ester 
• 126771-52-6 (S)-3-(4-tert-Butoxy-phenyl)-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid 4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl ester 
• 126771-48-0 (S)-2-(9H-Fluoren-9-ylmethoxycarbonylamino)-3-(1H-indol-3-yl)-propionic acid 4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl ester 
• 126771-45-7 (S)-3-tert-Butoxy-2-(9H-fluoren-9-ylmethoxycarbonylamino)-propionic acid 4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl ester 
• 126771-49-1 (S)-Pyrrolidine-1,2-dicarboxylic acid 2-[4-(2,4-dichloro-phenoxycarbonylmethoxy)-benzyl] ester 1-(9H-fluoren-9-ylmethyl) ester 

Relevant academic research and scientific papers

A convenient, large-scale preparation of 2,4-dichlorophenyl-4- bromomethyl-phenoxyacetate suitable for resin anchorage of the first Fmoc amino acid

2,4-dichlorophenyl-4-bromomethyl-phenoxyacetate 3 was prepared by NBS treatment of 2,4-dichlorophenyl-4-methylphenoxacetate 2. This ester is a key intermediate in the preparation of 2,4-dichlorophenyl-N(α)-Fmoc-aminoacyl- 4-oxymethylphenoxy-acetates suitable for anchorage of the first amino acid on amine-functionalized polymers.

AN EFFICIENT METHOD FOR RACEMIZATION FREE ATTACHMENT OF 9-FLUORENYLMETHYLOXYCARBONYL-AMINO ACIDS TO PEPTIDE SYNTHESIS SUPPORTS

An efficient, general, and racemization free method of covalently attaching N α-Fmoc protected amino acids to solid supports for peptide synthesis is described.The process involves the preparation of 2,4-dichlorophenyl-N α-Fmoc- aminoacyl-4-oxymethyl-phen