Technology Process of cyclo<-Tyr-Arg-D-Lys-Glu-D-Val->*2AcOH
There total 40 articles about cyclo<-Tyr-Arg-D-Lys-Glu-D-Val->*2AcOH which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
hydrogen;
palladium on activated charcoal;
In
methanol;
for 6h;
Ambient temperature;
DOI:10.1002/jlac.198619860507
- Guidance literature:
-
Multi-step reaction with 5 steps
1: 89 percent / NMM,PPA / CH2Cl2 / 1.) -15 degC to room temp., 2.) 2d, room temp.
2: 73 percent / TFA / CH2Cl2 / 0.5 h / Ambient temperature
3: 46 percent / PPA,NMM / CH2Cl2 / 1.) -15 deg C to room temp., 2:) 2d room temp.
4: 1.)TFA, 2.) NMM,DMAP,EDCI / 1.) DMF/CH2Cl2, 5d, -2 to 5 degC, 2.) 1d, room temp.
5: hydrogen / 10percent Pd/C / methanol / 6 h / Ambient temperature
With
4-methyl-morpholine; dmap; PPA,NMM; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid;
palladium on activated charcoal;
In
methanol; dichloromethane;
DOI:10.1002/jlac.198619860507
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 68 percent / PPA,NMM / CH2Cl2 / 1.) -15 deg C to room temp., 2:) 2d room temp.
2: 1.)TFA, 2.) NMM,DMAP,EDCI / 1.) DMF/CH2Cl2, 5d, -2 to 5 degC, 2.) 1d, room temp.
3: hydrogen / 10percent Pd/C / methanol / 6 h / Ambient temperature
With
4-methyl-morpholine; dmap; PPA,NMM; hydrogen; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; trifluoroacetic acid;
palladium on activated charcoal;
In
methanol; dichloromethane;
DOI:10.1002/jlac.198619860507