7-(2-chloro-6-ethoxypyridin-4-yl)-9-(2,4-dichlorophenyl)-2-methylpyrido[3',2':4,5]thieno[3,2-d]-pyrimidin-4(3H)-one

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Chemical Name:7-(2-chloro-6-ethoxypyridin-4-yl)-9-(2,4-dichlorophenyl)-2-methylpyrido[3',2':4,5]thieno[3,2-d]-pyrimidin-4(3H)-one
CAS No.:1421674-36-3
Molecular Formula:C₂₃H₁₅Cl₃N₄O₂S
Molecular Weight:517.823
Hs Code.:

Synonyms:7-(2-chloro-6-ethoxypyridin-4-yl)-9-(2,4-dichlorophenyl)-2-methylpyrido[3',2':4,5]thieno[3,2-d]-pyrimidin-4(3H)-one

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Chemical Property of 7-(2-chloro-6-ethoxypyridin-4-yl)-9-(2,4-dichlorophenyl)-2-methylpyrido[3',2':4,5]thieno[3,2-d]-pyrimidin-4(3H)-one

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Technology Process of 7-(2-chloro-6-ethoxypyridin-4-yl)-9-(2,4-dichlorophenyl)-2-methylpyrido[3',2':4,5]thieno[3,2-d]-pyrimidin-4(3H)-one

There total 4 articles about 7-(2-chloro-6-ethoxypyridin-4-yl)-9-(2,4-dichlorophenyl)-2-methylpyrido[3',2':4,5]thieno[3,2-d]-pyrimidin-4(3H)-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 65.0%

: 1421674-33-0
7-(2-chloro-6-ethoxypyridin-4-yl)-9-(2,4-dichlorophenyl)-2-methyl-4H-pyrido[3',2':4,5]thieno[3,2-d]-[1,3]oxazin-4-one

: 1421674-36-3
7-(2-chloro-6-ethoxypyridin-4-yl)-9-(2,4-dichlorophenyl)-2-methylpyrido[3',2':4,5]thieno[3,2-d]-pyrimidin-4(3H)-one

Guidance literature:: With ammonium acetate; In acetic acid; for 6h; Reflux;
DOI:10.3390/molecules171113642

Reference yield:

: 177172-20-2
2-chloro-6-ethoxy-4-acetylpyridine

: 1421674-36-3
7-(2-chloro-6-ethoxypyridin-4-yl)-9-(2,4-dichlorophenyl)-2-methylpyrido[3',2':4,5]thieno[3,2-d]-pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 7 steps

1.1: triethylamine; N,N-diethylaniline / ethanol / 6 h / Reflux

2.1: ammonium acetate / ethanol / 5 h / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

3.2: 2 h / 60 °C

4.1: sodium methylate / 1 h / 70 °C

5.1: sodium hydroxide / ethanol / 4 h / Reflux

6.1: 6 h / Reflux

7.1: ammonium acetate / acetic acid / 6 h / Reflux

With ammonium acetate; sodium methylate; potassium carbonate; triethylamine; N,N-diethylaniline; sodium hydroxide; In ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.3390/molecules171113642

Reference yield:

: 1421674-21-6
6-(2-chloro-6-ethoxypyridin-4-yl)-4-(2,4-dichlorophenyl)-1,2-dihydro-2-thioxopyridine-3-carbonitrile

: 1421674-36-3
7-(2-chloro-6-ethoxypyridin-4-yl)-9-(2,4-dichlorophenyl)-2-methylpyrido[3',2':4,5]thieno[3,2-d]-pyrimidin-4(3H)-one

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

1.2: 2 h / 60 °C

2.1: sodium methylate / 1 h / 70 °C

3.1: sodium hydroxide / ethanol / 4 h / Reflux

4.1: 6 h / Reflux

5.1: ammonium acetate / acetic acid / 6 h / Reflux

With ammonium acetate; sodium methylate; potassium carbonate; sodium hydroxide; In ethanol; acetic acid; N,N-dimethyl-formamide;
DOI:10.3390/molecules171113642