7-(2-chloro-6-ethoxypyridin-4-yl)-9-(2,4-dichlorophenyl)-2-methyl-4H-pyrido[3',2':4,5]thieno[3,2-d]-[1,3]oxazin-4-one

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Chemical Name:7-(2-chloro-6-ethoxypyridin-4-yl)-9-(2,4-dichlorophenyl)-2-methyl-4H-pyrido[3',2':4,5]thieno[3,2-d]-[1,3]oxazin-4-one
CAS No.:1421674-33-0
Molecular Formula:C₂₃H₁₄Cl₃N₃O₃S
Molecular Weight:518.807
Hs Code.:

Synonyms:7-(2-chloro-6-ethoxypyridin-4-yl)-9-(2,4-dichlorophenyl)-2-methyl-4H-pyrido[3',2':4,5]thieno[3,2-d]-[1,3]oxazin-4-one

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Chemical Property of 7-(2-chloro-6-ethoxypyridin-4-yl)-9-(2,4-dichlorophenyl)-2-methyl-4H-pyrido[3',2':4,5]thieno[3,2-d]-[1,3]oxazin-4-one

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Technology Process of 7-(2-chloro-6-ethoxypyridin-4-yl)-9-(2,4-dichlorophenyl)-2-methyl-4H-pyrido[3',2':4,5]thieno[3,2-d]-[1,3]oxazin-4-one

There total 3 articles about 7-(2-chloro-6-ethoxypyridin-4-yl)-9-(2,4-dichlorophenyl)-2-methyl-4H-pyrido[3',2':4,5]thieno[3,2-d]-[1,3]oxazin-4-one which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 60.0%

: C₂₁H₁₃Cl₃N₃O₃S^(1-)*Na⁽¹⁺⁾

: 108-24-7
acetic anhydride

: 1421674-33-0
7-(2-chloro-6-ethoxypyridin-4-yl)-9-(2,4-dichlorophenyl)-2-methyl-4H-pyrido[3',2':4,5]thieno[3,2-d]-[1,3]oxazin-4-one

Guidance literature:: for 6h; Reflux;
DOI:10.3390/molecules171113642

Reference yield:

: 177172-20-2
2-chloro-6-ethoxy-4-acetylpyridine

: 1421674-33-0
7-(2-chloro-6-ethoxypyridin-4-yl)-9-(2,4-dichlorophenyl)-2-methyl-4H-pyrido[3',2':4,5]thieno[3,2-d]-[1,3]oxazin-4-one

Guidance literature:: Multi-step reaction with 6 steps

1.1: triethylamine; N,N-diethylaniline / ethanol / 6 h / Reflux

2.1: ammonium acetate / ethanol / 5 h / Reflux

3.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

3.2: 2 h / 60 °C

4.1: sodium methylate / 1 h / 70 °C

5.1: sodium hydroxide / ethanol / 4 h / Reflux

6.1: 6 h / Reflux

With ammonium acetate; sodium methylate; potassium carbonate; triethylamine; N,N-diethylaniline; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.3390/molecules171113642

Reference yield:

: 1421674-21-6
6-(2-chloro-6-ethoxypyridin-4-yl)-4-(2,4-dichlorophenyl)-1,2-dihydro-2-thioxopyridine-3-carbonitrile

: 1421674-33-0
7-(2-chloro-6-ethoxypyridin-4-yl)-9-(2,4-dichlorophenyl)-2-methyl-4H-pyrido[3',2':4,5]thieno[3,2-d]-[1,3]oxazin-4-one

Guidance literature:: Multi-step reaction with 4 steps

1.1: potassium carbonate / N,N-dimethyl-formamide / 2 h / 20 °C

1.2: 2 h / 60 °C

2.1: sodium methylate / 1 h / 70 °C

3.1: sodium hydroxide / ethanol / 4 h / Reflux

4.1: 6 h / Reflux

With sodium methylate; potassium carbonate; sodium hydroxide; In ethanol; N,N-dimethyl-formamide;
DOI:10.3390/molecules171113642