N-((1-((2-chloro-6-methylquinolin-3-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)-N-(2,2,4-trimethyl-7-phenoxy-1,2-dihydroquinolin-6-yl)methanesulfonamide

Base Information

Chemical Name:N-((1-((2-chloro-6-methylquinolin-3-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)-N-(2,2,4-trimethyl-7-phenoxy-1,2-dihydroquinolin-6-yl)methanesulfonamide
CAS No.:1601552-66-2
Molecular Formula:C₃₃H₃₃ClN₆O₃S
Molecular Weight:629.182
Hs Code.:

N-((1-((2-chloro-6-methylquinolin-3-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)-N-(2,2,4-trimethyl-7-phenoxy-1,2-dihydroquinolin-6-yl)methanesulfonamide

Synonyms:N-((1-((2-chloro-6-methylquinolin-3-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)-N-(2,2,4-trimethyl-7-phenoxy-1,2-dihydroquinolin-6-yl)methanesulfonamide

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Chemical Property of N-((1-((2-chloro-6-methylquinolin-3-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)-N-(2,2,4-trimethyl-7-phenoxy-1,2-dihydroquinolin-6-yl)methanesulfonamide

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Technology Process of N-((1-((2-chloro-6-methylquinolin-3-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)-N-(2,2,4-trimethyl-7-phenoxy-1,2-dihydroquinolin-6-yl)methanesulfonamide

There total 4 articles about N-((1-((2-chloro-6-methylquinolin-3-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)-N-(2,2,4-trimethyl-7-phenoxy-1,2-dihydroquinolin-6-yl)methanesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 86.0%

: 1234509-82-0
3-(azidomethyl)-2-chloro-6-methylquinoline

: 1601552-75-3
C₂₂H₂₄N₂O₃S

: 1601552-66-2
N-((1-((2-chloro-6-methylquinolin-3-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)-N-(2,2,4-trimethyl-7-phenoxy-1,2-dihydroquinolin-6-yl)methanesulfonamide

Guidance literature:: With copper(ll) sulfate pentahydrate; sodium L-ascorbate; In water; N,N-dimethyl-formamide; at 20 ℃;
DOI:10.1016/j.bioorg.2013.12.002

Reference yield:

: 51803-78-2
nimesulide

: 1601552-66-2
N-((1-((2-chloro-6-methylquinolin-3-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)-N-(2,2,4-trimethyl-7-phenoxy-1,2-dihydroquinolin-6-yl)methanesulfonamide

Guidance literature:: Multi-step reaction with 4 steps

1: potassium carbonate / acetone / 20 °C

2: tin; hydrogenchloride / 6 h / 90 °C

3: ammonium cerium (IV) nitrate / 20 h / 50 - 55 °C

4: copper(ll) sulfate pentahydrate; sodium L-ascorbate / N,N-dimethyl-formamide; water / 20 °C

With hydrogenchloride; tin; copper(ll) sulfate pentahydrate; ammonium cerium (IV) nitrate; potassium carbonate; sodium L-ascorbate; In water; N,N-dimethyl-formamide; acetone; 3: |Skraup Quinoline Synthesis;
DOI:10.1016/j.bioorg.2013.12.002

Reference yield:

: 1601552-74-2
C₁₆H₁₄N₂O₅S

: 1601552-66-2
N-((1-((2-chloro-6-methylquinolin-3-yl)methyl)-1H-1,2,3-triazol-4-yl)methyl)-N-(2,2,4-trimethyl-7-phenoxy-1,2-dihydroquinolin-6-yl)methanesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1: tin; hydrogenchloride / 6 h / 90 °C

2: ammonium cerium (IV) nitrate / 20 h / 50 - 55 °C

3: copper(ll) sulfate pentahydrate; sodium L-ascorbate / N,N-dimethyl-formamide; water / 20 °C

With hydrogenchloride; tin; copper(ll) sulfate pentahydrate; ammonium cerium (IV) nitrate; sodium L-ascorbate; In water; N,N-dimethyl-formamide; 2: |Skraup Quinoline Synthesis;
DOI:10.1016/j.bioorg.2013.12.002