Dinoprost tromethamine

Base Information

• Chemical Name: Dinoprost tromethamine
• CAS No.: 38562-01-5
• Deprecated CAS: 51553-13-0,36300-07-9,38473-38-0
• Molecular Formula: C20H34O5^.C4H11NO3
• Molecular Weight: 475.623
• Hs Code.: 2937500000
• European Community (EC) Number: 254-002-3
• NSC Number: 196515
• UNII: CT6BBQ5A68
• DSSTox Substance ID: DTXSID1045582
• Wikidata: Q106040920
• NCI Thesaurus Code: C1074
• Metabolomics Workbench ID: 145882
• ChEMBL ID: CHEMBL1200896
• Mol file: 38562-01-5.mol

Synonyms:dinoprost tromethamine;Lutalyse;Minprostin F2 Alpha;PGF2alpha tromethamine;prostaglandin F2alpha tromethamine;Prostin F2;Prostin F2 Alpha

Chemical Property of Dinoprost tromethamine

Chemical Property:

• Vapor Pressure: 1.71E-13mmHg at 25°C
• Melting Point: 25-35oC
• Boiling Point: 531 °C at 760 mmHg
• Flash Point: 289 °C
• PSA: 184.70000
• LogP: 1.40400
• Storage Temp.: −20°C
• Solubility.: H2O: 1 mg/mL Aqueous solutions are stable for 30 days at 2-
• Hydrogen Bond Donor Count: 8
• Hydrogen Bond Acceptor Count: 9
• Rotatable Bond Count: 15
• Exact Mass: 475.31451739
• Heavy Atom Count: 33
• Complexity: 486

Purity/Quality:

99% ^*data from raw suppliers

Prostaglandin F2α Tromethamine Salt ^*data from reagent suppliers

Safty Information:

• Pictogram(s): T
• Hazard Codes: T
• Statements: 60-22
• Safety Statements: 53-45

MSDS Files:

SDS file from LookChem

Total 1 MSDS from other Authors

Useful:

• Canonical SMILES: CCCCCC(C=CC1C(CC(C1CC=CCCCC(=O)O)O)O)O.C(C(CO)(CO)N)O
• Isomeric SMILES: CCCCC[C@@H](/C=C/[C@H]1[C@@H](C[C@@H]([C@@H]1C/C=C\CCCC(=O)O)O)O)O.C(C(CO)(CO)N)O
• Description: Dinoprost tromethamine is a synthetic analogue of prostaglandin. F2α is an autocrine hormone present in many mammalian tissues. It is used to cause luteolysis in the cow, sow and mare. It is given as a single injection by im or sc routes, the recommended dosage rate is 25 mg cow; 10 mg sow and 5 mg mare. It is rapidly absorbed from the injection site. It has an extremely short half life of only a few minutes, it is almost completely cleared following one or two passages through the liver and/or lungs.
• Uses: One of the most biologically studied of the primary prostaglandins. Closely related to Prostaglandin E2 (PGE2) in that both prostaglandins are biosynthesized from the same precursors and that PGF2 is the synthetic reduction product of PGE2. Phospholipase A2 (PLA2) is a key enzyme for biosynthesis of PGF2α. Oxytocic; abortifacient. One of the most biologically studied of the primary prostaglandins. Closely related to Prostaglandin E2 (PGE2) in that both prostaglandins are biosynthesized from the same precursors and that PGF2 is the synthetic reduction product of PGE2. Phospholipase A2 (PLA2) is a key enzyme for biosynthesis of PGF2α. Oxytocic; abortifacient.
• Indications: Dinoprost tromethamine salt (Prostaglandin F2α tromethamine salt) is an orally active, potent prostaglandin F (PGF) receptor (FP receptor) agonist. Dinoprost tromethamine salt is a luteolytic hormone produced locally in the endometrial luminal epithelium and corpus luteum (CL). Dinoprost tromethamine salt plays a key role in the onset and progression of labour.
• Therapeutic Function: Smooth muscle stimulant

Technology Process of Dinoprost tromethamine

There total 17 articles about Dinoprost tromethamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 92.5%

dinoprost (551-11-1) + 2-amino-2-hydroxymethyl-1,3-propanediol (77-86-1) → dinoprost tromethamine (38562-01-5,89847-02-9)

Guidance literature:

dinoprost; In acetonitrile; at 43 - 47 ℃; for 0.25h;

2-amino-2-hydroxymethyl-1,3-propanediol; In water; acetonitrile; at 53 - 57 ℃; for 0.0833333h;

Reference yield:

→ dinoprost (551-11-1) + dinoprost tromethamine (38562-01-5,89847-02-9)

Guidance literature:

Reference yield:

(S)-3-((S)-2-(4,4-pentamethylene-3-(4-(3-(2-methylphenyl)ureido)benzyl)-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetylamino)-3-phenylpropionic acid (306768-49-0) → dinoprost tromethamine (38562-01-5,89847-02-9)

Guidance literature:

upstream raw materials:

(S)-3-((S)-2-(4,4-pentamethylene-3-(4-(3-(2-methylphenyl)ureido)benzyl)-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetylamino)-3-phenylpropionic acid

(S)-3-((S)-2-(4,4-pentamethylene-3-(4-(3-phenylureido)benzyl)-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetylamino)-3-(4-methoxyphenyl)propionic acid

(S)-3-((S)-2-(4,4-pentamethylene-3-(4-(3-phenylureido)benzyl)-2,5-dioxoimidazolidin-1-yl)-2-(2-methylpropyl)acetylamino)-3-(2,4-dimethoxyphenyl)propionic acid

(3S)-(3,4-dimethoxyphenyl)-3-[(2S)-{2,4-dioxo-1-[4-(3-phenylureido)benzyl]-1,3-diazaspiro[4.5]dec-3-yl}-4-methylpentanoylamino]propionic acid

Refernces

• 1、 -. "Novel inhibitors of chymase". . . Retrieved 2010/03/31.
• 2、 -. "Spiroimidazolidine derivatives, their preparation, their use and pharmaceutical preparations formed therefrom". . . Retrieved 2008/06/13.