4-(diduetero-{ [6-(3-methoxy-benzylcarbamoyl)-pyrimidine-4-carbonyl]-amino}-methyl)-benzoic acid

Base Information

Chemical Name:4-(diduetero-{ [6-(3-methoxy-benzylcarbamoyl)-pyrimidine-4-carbonyl]-amino}-methyl)-benzoic acid
CAS No.:1605325-11-8
Molecular Formula:C₂₂H₂₀N₄O₅
Molecular Weight:422.409
Hs Code.:

Synonyms:4-(diduetero-{ [6-(3-methoxy-benzylcarbamoyl)-pyrimidine-4-carbonyl]-amino}-methyl)-benzoic acid

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Chemical Property of 4-(diduetero-{ [6-(3-methoxy-benzylcarbamoyl)-pyrimidine-4-carbonyl]-amino}-methyl)-benzoic acid

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Technology Process of 4-(diduetero-{ [6-(3-methoxy-benzylcarbamoyl)-pyrimidine-4-carbonyl]-amino}-methyl)-benzoic acid

There total 5 articles about 4-(diduetero-{ [6-(3-methoxy-benzylcarbamoyl)-pyrimidine-4-carbonyl]-amino}-methyl)-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 48.0%

: 1605325-10-7
4-(dideutero-{[6-(3-methoxy-benzylcarbamoyl)-pyrimidine-4-carbonyl]-amino}-methyl)-benzoic acid methyl ester

: 1605325-11-8
4-(diduetero-{ [6-(3-methoxy-benzylcarbamoyl)-pyrimidine-4-carbonyl]-amino}-methyl)-benzoic acid

Guidance literature:: With [D]-sodium hydroxide; water-d2; In tetrahydrofuran; d⁽⁴⁾-methanol; for 2.5h;

Reference yield:

: 6345-43-3
pyrimidine-4,6-dicarboxylic acid dimethyl ester

: 1605325-11-8
4-(diduetero-{ [6-(3-methoxy-benzylcarbamoyl)-pyrimidine-4-carbonyl]-amino}-methyl)-benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: methanol; sodium hydroxide / 1 h / 20 °C / Inert atmosphere

2.1: 1-hydroxy-7-aza-benzotriazole; HATU / N,N-dimethyl-formamide / 0.08 h / 20 °C / Inert atmosphere

2.2: 24 h / Inert atmosphere

3.1: potassium hydroxide; water / tetrahydrofuran / 4 h

4.1: 1-hydroxy-7-aza-benzotriazole; HATU / N,N-dimethyl-formamide

4.2: 24 h / Inert atmosphere

5.1: [D]-sodium hydroxide; water-d2 / d⁽⁴⁾-methanol; tetrahydrofuran / 2.5 h

With methanol; 1-hydroxy-7-aza-benzotriazole; [D]-sodium hydroxide; water; water-d2; HATU; potassium hydroxide; sodium hydroxide; In tetrahydrofuran; d⁽⁴⁾-methanol; N,N-dimethyl-formamide;

Reference yield:

: 6-(3-methoxy-benzylcarbamoyl)-pyrimidine-4-carboxylic acid

: 1605325-11-8
4-(diduetero-{ [6-(3-methoxy-benzylcarbamoyl)-pyrimidine-4-carbonyl]-amino}-methyl)-benzoic acid

Guidance literature:: Multi-step reaction with 2 steps

1.1: 1-hydroxy-7-aza-benzotriazole; HATU / N,N-dimethyl-formamide

1.2: 24 h / Inert atmosphere

2.1: [D]-sodium hydroxide; water-d2 / d⁽⁴⁾-methanol; tetrahydrofuran / 2.5 h

With 1-hydroxy-7-aza-benzotriazole; [D]-sodium hydroxide; water-d2; HATU; In tetrahydrofuran; d⁽⁴⁾-methanol; N,N-dimethyl-formamide;