Dimethyl pyrimidine-4,6-dicarboxylate

Base Information

Chemical Name:Dimethyl pyrimidine-4,6-dicarboxylate
CAS No.:6345-43-3
Molecular Formula:C8H8N2O4
Molecular Weight:196.163
Hs Code.:2933599090
European Community (EC) Number:929-172-3
NSC Number:44349
DSSTox Substance ID:DTXSID70286238
Nikkaji Number:J2.021.670K
Wikidata:Q82021896
Mol file:6345-43-3.mol

Synonyms:dimethyl pyrimidine-4,6-dicarboxylate;6345-43-3;4,6-DIMETHYL PYRIMIDINE-4,6-DICARBOXYLATE;DIMETHYL 4,6-PYRIMIDINEDICARBOXYLATE;MFCD05864412;NSC 44349;pyrimidine-4,6-dicarboxylic acid dimethyl ester;NSC44349;4,6-Pyrimidinedicarboxylic acid, dimethyl ester;SCHEMBL4000055;DTXSID70286238;NSC-44349;AKOS006344013;PB12841;NS-01932;BB 0257619;CS-0045800;FT-0693241;P10328;A868133;PYRIMIDINE-4,6-DICARBOXYLIC ACID DIMETHYL ESTER;4,6-PyriMidinedicarboxylic acid, 4,6-diMethyl ester

Suppliers and Price of Dimethyl pyrimidine-4,6-dicarboxylate

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

TRC
Dimethyl4,6-Pyrimidinedicarboxylate
250mg
$ 105.00

TRC
Dimethyl4,6-Pyrimidinedicarboxylate
1g
$ 305.00

SynQuest Laboratories
4,6-Dimethyl pyrimidine-4,6-dicarboxylate 97.0%
5 g
$ 628.00

SynQuest Laboratories
4,6-Dimethyl pyrimidine-4,6-dicarboxylate 97.0%
1 g
$ 390.00

SynQuest Laboratories
4,6-Dimethyl pyrimidine-4,6-dicarboxylate 97.0%
250 mg
$ 160.00

Crysdot
Dimethylpyrimidine-4,6-dicarboxylate 95+%
1g
$ 92.00

Crysdot
Dimethylpyrimidine-4,6-dicarboxylate 95+%
5g
$ 352.00

Crysdot
Dimethylpyrimidine-4,6-dicarboxylate 95+%
25g
$ 1016.00

Crysdot
Dimethylpyrimidine-4,6-dicarboxylate 95+%
10g
$ 566.00

Chemenu
4,6-dimethylpyrimidine-4,6-dicarboxylate 95%
10g
$ 535.00

Total 23 raw suppliers

Chemical Property of Dimethyl pyrimidine-4,6-dicarboxylate

Chemical Property:

Vapor Pressure:0.000811mmHg at 25°C
Melting Point:78-79 °C
Refractive Index:1.518
Boiling Point:305.7 °C at 760 mmHg
PKA:-3.53±0.17(Predicted)
Flash Point:138.7 °C
PSA：78.38000
Density:1.293 g/cm³
LogP:0.04980
Storage Temp.:Sealed in dry,Room Temperature
XLogP3:0.6
Hydrogen Bond Donor Count:0
Hydrogen Bond Acceptor Count:6
Rotatable Bond Count:4
Exact Mass:196.04840674
Heavy Atom Count:14
Complexity:209

Purity/Quality:

99%, ^*data from raw suppliers

Dimethyl4,6-Pyrimidinedicarboxylate ^*data from reagent suppliers

Safty Information:

Pictogram(s):
Hazard Codes:
Statements: 36/37/38
Safety Statements: 26-36/37/39

MSDS Files:: SDS file from LookChem

Useful:

Canonical SMILES:COC(=O)C1=CC(=NC=N1)C(=O)OC
Uses Dimethyl 4,6-Pyrimidinedicarboxylate is a compound involved in the preparation of radiolabeled selective matrix metalloproteinase 13 (MMP-13) inhibitors.

Technology Process of Dimethyl pyrimidine-4,6-dicarboxylate

There total 3 articles about Dimethyl pyrimidine-4,6-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.4%

: 67-56-1
methanol

: 16490-02-1
pyrimidine-4,6-dicarboxylic acid

: 6345-43-3
pyrimidine-4,6-dicarboxylic acid dimethyl ester

Guidance literature:: With hydrogenchloride; In water; at 65 ℃; for 3h; Heating / reflux;

Reference yield:

: 1558-17-4
4,6-dimethylpyrimidine

: 6345-43-3
pyrimidine-4,6-dicarboxylic acid dimethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: sodium hydroxide; potassium permanganate / water / 3 h / 80 °C

2: sulfuric acid / 24 h / Reflux

With potassium permanganate; sulfuric acid; sodium hydroxide; In water;
DOI:10.1021/acs.jmedchem.6b01284