3-<4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoic acid, lactam

Base Information

Chemical Name:3-<4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoic acid, lactam
CAS No.:150460-87-0
Molecular Formula:C₂₈H₂₆N₂O₂S
Molecular Weight:454.593
Hs Code.:

Synonyms:3-<4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoic acid, lactam

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Chemical Property of 3-<4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoic acid, lactam

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Technology Process of 3-<4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoic acid, lactam

There total 8 articles about 3-<4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoic acid, lactam which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3256-88-0
5-phenyl-2-picoline

: 150460-87-0
3-<4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoic acid, lactam

Guidance literature:: Multi-step reaction with 2 steps

1: 45 percent / N-chlorosuccinimide, benzoyl peroxide / CCl₄ / 5 h / Heating; Irradiation

2: NaH / dimethylformamide / 1 h

With N-chloro-succinimide; Perbenzoic acid; sodium hydride; In tetrachloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00071a008

Reference yield:

: 147936-58-1
5-phenyl-2-picoline N-oxide

: 150460-87-0
3-<4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoic acid, lactam

Guidance literature:: Multi-step reaction with 2 steps

1: 61 percent / phosphoryl chloride, Et₃N / CH₂Cl₂

2: NaH / dimethylformamide / 1 h

With sodium hydride; triethylamine; trichlorophosphate; In dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm00071a008

Reference yield:

: methyl 5-(t-butylthio)-2,2-dimethyl-4-oxopentanoate

: 150460-87-0
3-<4-methyl-6-<(5-phenylpyridin-2-yl)methoxy>-4,5-dihydro-1H-thiopyrano<2,3,4-c,d>indol-2-yl>-2,2-dimethylpropanoic acid, lactam

Guidance literature:: Multi-step reaction with 5 steps

1: 55 percent / 2-methyl-propan-2-ol / 24 h / Heating

2: 62 percent / pyridine hydrochloride / 2 h / 175 °C

3: 1.) NaH / 1.) DMF, 25 deg C, 10 min, 2.) DMF, 16 h

4: 2.) p-toluenesulfonic acid / 1.) 1,2-dichlorobenzene, reflux, 16 h, 2.) 1,2-dichlorobenzene, 150 deg C, 45 min

5: NaH / dimethylformamide / 1 h

With pyridine hydrochloride; sodium hydride; toluene-4-sulfonic acid; In N,N-dimethyl-formamide; tert-butyl alcohol;
DOI:10.1021/jm00071a008