6-methyl-N⁴-(1-propyl-butyl)-N²-(4-trifluoromethyl-phenyl)-pyridine-2,3,4-triamine

Base Information

• Chemical Name: 6-methyl-N⁴-(1-propyl-butyl)-N²-(4-trifluoromethyl-phenyl)-pyridine-2,3,4-triamine
• CAS No.: 863920-78-9
• Molecular Formula: C₂₀H₂₇F₃N₄
• Molecular Weight: 380.456

Synonyms:6-methyl-N⁴-(1-propyl-butyl)-N²-(4-trifluoromethyl-phenyl)-pyridine-2,3,4-triamine

Chemical Property of 6-methyl-N⁴-(1-propyl-butyl)-N²-(4-trifluoromethyl-phenyl)-pyridine-2,3,4-triamine

Chemical Property:

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Technology Process of 6-methyl-N⁴-(1-propyl-butyl)-N²-(4-trifluoromethyl-phenyl)-pyridine-2,3,4-triamine

There total 6 articles about 6-methyl-N⁴-(1-propyl-butyl)-N²-(4-trifluoromethyl-phenyl)-pyridine-2,3,4-triamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

6-methyl-3-nitro-N4-(1-propyl-butyl)-N2-(4-trifluoromethyl-phenyl)-pyridine-2,4-diamine (863920-67-6) → 6-methyl-N4-(1-propyl-butyl)-N2-(4-trifluoromethyl-phenyl)-pyridine-2,3,4-triamine (863920-78-9)

Guidance literature:

With sodium hydroxide; sodium disulfite; In tetrahydrofuran; at 20 ℃;

DOI:10.1021/jm050384+

Reference yield:

2,4-Dihydroxy-6-methyl-3-nitropyridine (4966-90-9) → 6-methyl-N4-(1-propyl-butyl)-N2-(4-trifluoromethyl-phenyl)-pyridine-2,3,4-triamine (863920-78-9)

Guidance literature:

Multi-step reaction with 5 steps

1: triethylamine; 4-dimethylaminopyridine / tetrahydrofuran / 1 h / Heating

2: 1069 g / triethylamine / tetrahydrofuran / Heating

3: phosphorus oxychloride; DMF / acetonitrile / 2 h / 50 °C

4: acetonitrile / 65 °C

5: sodium hydrosulfite; aq. NaOH / tetrahydrofuran / 20 °C

With dmap; sodium hydroxide; sodium disulfite; triethylamine; N,N-dimethyl-formamide; trichlorophosphate; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jm050384+

Reference yield:

benzenesulfonic acid 2-hydroxy-6-methyl-3-nitro-pyridin-4-yl ester (1027728-77-3) → 6-methyl-N4-(1-propyl-butyl)-N2-(4-trifluoromethyl-phenyl)-pyridine-2,3,4-triamine (863920-78-9)

Guidance literature:

Multi-step reaction with 4 steps

1: 1069 g / triethylamine / tetrahydrofuran / Heating

2: phosphorus oxychloride; DMF / acetonitrile / 2 h / 50 °C

3: acetonitrile / 65 °C

4: sodium hydrosulfite; aq. NaOH / tetrahydrofuran / 20 °C

With sodium hydroxide; sodium disulfite; triethylamine; N,N-dimethyl-formamide; trichlorophosphate; In tetrahydrofuran; acetonitrile;

DOI:10.1021/jm050384+

upstream raw materials:

6-methyl-3-nitro-N⁴-(1-propyl-butyl)-N²-(4-trifluoromethyl-phenyl)-pyridine-2,4-diamine

benzenesulfonic acid 2-hydroxy-6-methyl-3-nitro-pyridin-4-yl ester

2-chloro-4-(4-heptyl)amino-6-methyl-3-nitropyridine

6-methyl-3-nitro-4-(1-propyl-butylamino)pyridin-2-ol

Downstream raw materials:

5-methyl-7-(1-propyl-butylamino)-3-(4-trifluoromethyl-phenyl)-1,3-dihydro-imidazo[4,5-b]pyridin-2-one

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