(R)-1-(2-bromobenzyl)-1,2,3,4-tetrahydro-6,7-dimethoxyiaoquinoline

Base Information

Chemical Name:(R)-1-(2-bromobenzyl)-1,2,3,4-tetrahydro-6,7-dimethoxyiaoquinoline
CAS No.:934355-85-8
Molecular Formula:C₁₈H₂₀BrNO₂
Molecular Weight:362.266
Hs Code.:

Synonyms:(R)-1-(2-bromobenzyl)-1,2,3,4-tetrahydro-6,7-dimethoxyiaoquinoline

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Chemical Property of (R)-1-(2-bromobenzyl)-1,2,3,4-tetrahydro-6,7-dimethoxyiaoquinoline

Chemical Property:

Purity/Quality:

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Technology Process of (R)-1-(2-bromobenzyl)-1,2,3,4-tetrahydro-6,7-dimethoxyiaoquinoline

There total 5 articles about (R)-1-(2-bromobenzyl)-1,2,3,4-tetrahydro-6,7-dimethoxyiaoquinoline which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 80041-81-2
1-(2-bromobenzyl)-3,4-dihydro-6,7-dimethoxyisoquinoline

: 934355-85-8
(R)-1-(2-bromobenzyl)-1,2,3,4-tetrahydro-6,7-dimethoxyiaoquinoline

: (S)-1-(2-bromobenzyl)-1,2,3,4-tetrahydro-6,7-dimethoxyisoquinoline

Guidance literature:: With formic acid; triethylamine; (S,S)-N-tosyl-1,2-diphenylethylenediamine Ru-complex; In N,N-dimethyl-formamide; at 20 ℃; for 1h; Title compound not separated from byproducts.;
DOI:10.1002/ejoc.200600674

Reference yield:

: 18698-97-0
ortho-bromophenylacetic acid

: 934355-85-8
(R)-1-(2-bromobenzyl)-1,2,3,4-tetrahydro-6,7-dimethoxyiaoquinoline

Guidance literature:: Multi-step reaction with 4 steps

1: (COCl₂); dimethylformamide / CH₂Cl₂ / 25 °C

2: Et₃N / CH₂Cl₂ / 25 °C

3: 99 percent / POCl₃ / CH₂Cl₂ / Heating

4: Et₃N; HCO₂H / (S,S)-N-tosyl-1,2-diphenylethylenediamine Ru-complex / dimethylformamide / 1 h / 20 °C

With phosgene; formic acid; triethylamine; N,N-dimethyl-formamide; trichlorophosphate; (S,S)-N-tosyl-1,2-diphenylethylenediamine Ru-complex; In dichloromethane; N,N-dimethyl-formamide; 3: Bischler-Napieralski cyclization;
DOI:10.1002/ejoc.200600674

Reference yield:

: 55116-09-1
2-bromophenylacetyl chloride

: 934355-85-8
(R)-1-(2-bromobenzyl)-1,2,3,4-tetrahydro-6,7-dimethoxyiaoquinoline

Guidance literature:: Multi-step reaction with 3 steps

1: Et₃N / CH₂Cl₂ / 25 °C

2: 99 percent / POCl₃ / CH₂Cl₂ / Heating

3: Et₃N; HCO₂H / (S,S)-N-tosyl-1,2-diphenylethylenediamine Ru-complex / dimethylformamide / 1 h / 20 °C

With formic acid; triethylamine; trichlorophosphate; (S,S)-N-tosyl-1,2-diphenylethylenediamine Ru-complex; In dichloromethane; N,N-dimethyl-formamide; 2: Bischler-Napieralski cyclization;
DOI:10.1002/ejoc.200600674