2-((3-((3S,4S)-1-benzyl-4-methylpyrrolidin-3-yl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)methyl)isoindoline-1,3-dione

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Chemical Name:2-((3-((3S,4S)-1-benzyl-4-methylpyrrolidin-3-yl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)methyl)isoindoline-1,3-dione
CAS No.:1369515-41-2
Molecular Formula:C₂₄H₂₃N₅O₃
Molecular Weight:429.478
Hs Code.:

Synonyms:2-((3-((3S,4S)-1-benzyl-4-methylpyrrolidin-3-yl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)methyl)isoindoline-1,3-dione

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Chemical Property of 2-((3-((3S,4S)-1-benzyl-4-methylpyrrolidin-3-yl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)methyl)isoindoline-1,3-dione

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Technology Process of 2-((3-((3S,4S)-1-benzyl-4-methylpyrrolidin-3-yl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)methyl)isoindoline-1,3-dione

There total 6 articles about 2-((3-((3S,4S)-1-benzyl-4-methylpyrrolidin-3-yl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)methyl)isoindoline-1,3-dione which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 38.0%

: (3S,4S)-1-benzyl-4-methylpyrrolidine-3-carboximidhydrazide hydrochloride

: 153646-24-3
methyl 3-(1,3-dioxoisoindolin-2-yl)-2-oxopropanoate

: 1369515-41-2
2-((3-((3S,4S)-1-benzyl-4-methylpyrrolidin-3-yl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)methyl)isoindoline-1,3-dione

Guidance literature:: (3S,4S)-1-benzyl-4-methylpyrrolidine-3-carboximidhydrazide hydrochloride; methyl 3-(1,3-dioxoisoindolin-2-yl)-2-oxopropanoate; In ethanol; for 17h; Reflux; Inert atmosphere;

With sodium hydrogencarbonate; In ethanol; chloroform;

Reference yield:

: 604798-83-6
(3S,4S)-1-benzyl-4-methylpyrrolidine-3-carboxylic acid

: 1369515-41-2
2-((3-((3S,4S)-1-benzyl-4-methylpyrrolidin-3-yl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)methyl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 4 steps

1.1: sulfuric acid / 4 h / 20 °C / Reflux

2.1: ammonium chloride; trimethylaluminum / n-heptane / 24 h / 0 - 80 °C / Inert atmosphere

3.1: hydrazine hydrate / ethanol / 2 h / 20 °C / Reflux

3.2: 0.5 h / 20 °C / Inert atmosphere

4.1: ethanol / 17 h / Reflux; Inert atmosphere

With sulfuric acid; trimethylaluminum; ammonium chloride; hydrazine hydrate; In ethanol; n-heptane;

Reference yield:

: 189506-93-2
(R)-3-((3S,4S)-1-benzyl-4-methylpyrrolidine-3-carbonyl)-4-phenyloxazolidin-2-one

: 1369515-41-2
2-((3-((3S,4S)-1-benzyl-4-methylpyrrolidin-3-yl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)methyl)isoindoline-1,3-dione

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium hydroxide; dihydrogen peroxide / water; tetrahydrofuran / 2 h / 0 °C

1.2: pH 4.6

2.1: sulfuric acid / 4 h / 20 °C / Reflux

3.1: ammonium chloride; trimethylaluminum / n-heptane / 24 h / 0 - 80 °C / Inert atmosphere

4.1: hydrazine hydrate / ethanol / 2 h / 20 °C / Reflux

4.2: 0.5 h / 20 °C / Inert atmosphere

5.1: ethanol / 17 h / Reflux; Inert atmosphere

With sulfuric acid; dihydrogen peroxide; trimethylaluminum; ammonium chloride; hydrazine hydrate; lithium hydroxide; In tetrahydrofuran; ethanol; n-heptane; water;