N-((3-((3S,4S)-1-benzyl-4-methylpyrrolidin-3-yl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)methyl)tetrahydro-2H-pyran-4-carboxamide

Base Information

Chemical Name:N-((3-((3S,4S)-1-benzyl-4-methylpyrrolidin-3-yl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)methyl)tetrahydro-2H-pyran-4-carboxamide
CAS No.:1369515-43-4
Molecular Formula:C₂₂H₂₉N₅O₃
Molecular Weight:411.504
Hs Code.:

Synonyms:N-((3-((3S,4S)-1-benzyl-4-methylpyrrolidin-3-yl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)methyl)tetrahydro-2H-pyran-4-carboxamide

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Chemical Property of N-((3-((3S,4S)-1-benzyl-4-methylpyrrolidin-3-yl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)methyl)tetrahydro-2H-pyran-4-carboxamide

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Technology Process of N-((3-((3S,4S)-1-benzyl-4-methylpyrrolidin-3-yl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)methyl)tetrahydro-2H-pyran-4-carboxamide

There total 10 articles about N-((3-((3S,4S)-1-benzyl-4-methylpyrrolidin-3-yl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)methyl)tetrahydro-2H-pyran-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 71.0%

: 61274-13-3
succinimidyl cyclohexanecarboxylate

: 1369515-42-3
6-(aminomethyl)-3-((3S,4S)-1-benzyl-4-methylpyrrolidin-3-yl)-1,2,4-triazin-5(4H)-one

: 1369515-43-4
N-((3-((3S,4S)-1-benzyl-4-methylpyrrolidin-3-yl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)methyl)tetrahydro-2H-pyran-4-carboxamide

Guidance literature:: In dichloromethane; at 20 ℃; for 20h;

Reference yield: 71.0%

: 1369515-33-2
2,5-dioxopyrrolidin-1-yl tetrahydro-2H-pyran-4-carboxylate

: 1369515-42-3
6-(aminomethyl)-3-((3S,4S)-1-benzyl-4-methylpyrrolidin-3-yl)-1,2,4-triazin-5(4H)-one

: 1369515-43-4
N-((3-((3S,4S)-1-benzyl-4-methylpyrrolidin-3-yl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)methyl)tetrahydro-2H-pyran-4-carboxamide

Guidance literature:: In dichloromethane; at 20 ℃; for 20h;

Reference yield:

: 604798-83-6
(3S,4S)-1-benzyl-4-methylpyrrolidine-3-carboxylic acid

: 1369515-43-4
N-((3-((3S,4S)-1-benzyl-4-methylpyrrolidin-3-yl)-5-oxo-4,5-dihydro-1,2,4-triazin-6-yl)methyl)tetrahydro-2H-pyran-4-carboxamide

Guidance literature:: Multi-step reaction with 6 steps

1.1: sulfuric acid / 4 h / 20 °C / Reflux

2.1: ammonium chloride; trimethylaluminum / n-heptane / 24 h / 0 - 80 °C / Inert atmosphere

3.1: hydrazine hydrate / ethanol / 2 h / 20 °C / Reflux

3.2: 0.5 h / 20 °C / Inert atmosphere

4.1: ethanol / 17 h / Reflux; Inert atmosphere

5.1: hydrazine hydrate / dichloromethane; ethanol / 5 h / 20 °C / Reflux

6.1: dichloromethane / 20 h / 20 °C

With sulfuric acid; trimethylaluminum; ammonium chloride; hydrazine hydrate; In ethanol; n-heptane; dichloromethane;