N-{3-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-propoxy]-2-cyano-phenyl}-succinamic acid ethyl ester

Base Information

Chemical Name:N-{3-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-propoxy]-2-cyano-phenyl}-succinamic acid ethyl ester
CAS No.:101836-02-6
Molecular Formula:C₂₇H₃₂N₂O₇
Molecular Weight:496.56
Hs Code.:

Synonyms:N-{3-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-propoxy]-2-cyano-phenyl}-succinamic acid ethyl ester

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Chemical Property of N-{3-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-propoxy]-2-cyano-phenyl}-succinamic acid ethyl ester

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Technology Process of N-{3-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-propoxy]-2-cyano-phenyl}-succinamic acid ethyl ester

There total 5 articles about N-{3-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-propoxy]-2-cyano-phenyl}-succinamic acid ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 15.0%

: 14794-31-1,97900-84-0
ethyl 3-(chloroformyl)propionate

: 101836-08-2
2-amino-6-[3-(4-acetyl-3-hydroxy-2-n-propylphenoxy)-propoxy]-benzonitrile

: 101836-02-6
N-{3-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-propoxy]-2-cyano-phenyl}-succinamic acid ethyl ester

Guidance literature:: In dichloromethane; 1.) 0 deg C, 40 min, 2.) 25 deg C, 3 h;
DOI:10.1021/jm00157a004

Reference yield:

: 40786-20-7
4-<(3-bromopropyl)oxy>-2-hydroxy-3-propylacetophenone

: 101836-02-6
N-{3-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-propoxy]-2-cyano-phenyl}-succinamic acid ethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: K₂CO₃, KI / acetone / 19 h / Heating

2: 48 percent / H₂, cyclohexene / 10percent Pd/C / ethanol / 0.5 h / Heating

3: 15 percent / CH₂Cl₂ / 1.) 0 deg C, 40 min, 2.) 25 deg C, 3 h

With hydrogen; potassium carbonate; potassium iodide; cyclohexene; palladium on activated charcoal; In ethanol; dichloromethane; acetone;
DOI:10.1021/jm00157a004

Reference yield:

: 38469-85-1
2-methoxy-6-nitrobenzonitrile

: 101836-02-6
N-{3-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-propoxy]-2-cyano-phenyl}-succinamic acid ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1: 88 percent / pyridine hydrochloride / 0.33 h / 200 °C

2: K₂CO₃, KI / acetone / 19 h / Heating

3: 48 percent / H₂, cyclohexene / 10percent Pd/C / ethanol / 0.5 h / Heating

4: 15 percent / CH₂Cl₂ / 1.) 0 deg C, 40 min, 2.) 25 deg C, 3 h

With hydrogen; pyridine hydrochloride; potassium carbonate; potassium iodide; cyclohexene; palladium on activated charcoal; In ethanol; dichloromethane; acetone;
DOI:10.1021/jm00157a004