40786-20-7

Basic information

• Product Name: 1-[4-(3-BROMOPROPOXY)-2-HYDROXY-3-PROPYLPHENYL]ETHAN-1-ONE
• Synonyms: 1-[4-(3-BROMOPROPOXY)-2-HYDROXY-3-PROPYLPHENYL]ETHAN-1-ONE;4-(3-Bromopropoxy)-2-hydroxy-3-propylacetophenone;1-[4-(3-Bromopropoxy)-2-hydroxy-3-propylphenyl]ethanone;1-[4-(3-broMopropoxy)-2-hydroxy-3-propylphenyl]-
• CAS NO: 40786-20-7
• Molecular Formula: C₁₄H₁₉BrO₃
• Molecular Weight: 315.2
• Product Categories: API intermediates
• Mol File: 40786-20-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 431.9°C at 760 mmHg
• Flash Point: 215°C
• Appearance: /
• Density: 1.319g/cm³
• Vapor Pressure: 4.6E-08mmHg at 25°C
• Refractive Index: 1.549
• PKA: 10.28±0.15(Predicted)
• CAS DataBase Reference: 1-[4-(3-BROMOPROPOXY)-2-HYDROXY-3-PROPYLPHENYL]ETHAN-1-ONE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-[4-(3-BROMOPROPOXY)-2-HYDROXY-3-PROPYLPHENYL]ETHAN-1-ONE(40786-20-7)
• EPA Substance Registry System: 1-[4-(3-BROMOPROPOXY)-2-HYDROXY-3-PROPYLPHENYL]ETHAN-1-ONE(40786-20-7)

Safety Data

• Hazardous Substances Data: 40786-20-7(Hazardous Substances Data)

Usage

Preparation

Preparation by reaction of 1,3-dibromopropane with 2,4-di-hydroxy-3-propylacetophenone in the presence of potassium carbonate and potassium iodide in refluxing acetone.

InChI:InChI=1/C14H19BrO3/c1-3-5-12-13(18-9-4-8-15)7-6-11(10(2)16)14(12)17/h6-7,17H,3-5,8-9H2,1-2H3

Upstream product

• 120072-78-8 methyl 1,2,3,4-tetrahydro-7-hydroxy-8-propyl-2-naphthalenecarboxylate 
• 40786-69-4 1-(2,4-dihydroxy-3-propylphenyl)ethanone 
• 109-64-8 1,3-dibromo-propane 

Downstream Products

• 101836-06-0 3-[3-(4-acetyl-3-hydroxy-2-n-propylphenoxy)-propoxy]-nitrobenzene 
• 101836-05-9 2-<3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy>-6-nitrobenzonitrile 
• 91541-40-1 4-{4-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-propylsulfanyl]-phenyl}-4-oxo-butyronitrile 
• 91361-93-2 {4-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-propylsulfanyl]-phenyl}-acetic acid methyl ester 
• 91541-92-3 4-{4-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-propylsulfanyl]-phenyl}-4-oxo-butyric acid methyl ester 
• 91584-73-5 (4R,5R)-5-{4-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-propylsulfanyl]-phenyl}-4-methyl-dihydro-furan-2-one 
• 91584-73-5 (4S,5R)-5-{4-[3-(4-Acetyl-3-hydroxy-2-propyl-phenoxy)-propylsulfanyl]-phenyl}-4-methyl-dihydro-furan-2-one 
• 120130-71-4 8-[3-(2-propyl-3-hydroxy-4-acetylphenoxy)propyl]-1-oxa-2-oxo-3,8-diaza-spiro[4.5]decane 
• 120130-81-6 8-[3-(2-propyl-3-hydroxy-4-acetylphenoxy)propyl]-1-oxa-2-oxo-3,8-diaza-4-methyl-spiro[4.5]decane 
• 41432-82-0 7-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]-4-oxo-8-propyl-4H-1-benzopyran-2-carboxylic acid 
• 929093-93-6 2-{3-[3-(4-acetyl-3-hydroxy-2-propyl-phenoxy)-propoxy]-5-butoxy-phenyl}-2-methyl-propionitrile 
• 122076-12-4 methyl 7-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]-1,2,3,4-tetrahydro-6-propyl-2-naphthalenecarboxylate 
• 120072-79-9 methyl 7-[3-(4-acetyl-3-hydroxy-2-propylphenoxy)propoxy]-1,2,3,4-tetrahydro-8-propyl-2-naphthalenecarboxylate 

Relevant articles and documents

Alkoxy-substituted dihydrobenzopyran-2-carboxylate derivatives.

This invention encompasses compounds of Formula 1 and the pharmaceutically acceptable salts thereof. wherein R1 represents alkyl having 2-6 carbon atoms; R2 represents methyl or ethyl; R3 represents alkyl having 1 to 5 carbon atoms; W represents (CH?)x where x is 2 to 7, alkylene having 2 to 7 carbon atoms, alkenylene having 3 to 7 carbon atoms, alkynylene having 3 to 7 carbon atoms, or cyclopentyl; R? represents hydrogen, alkyl having 2-5 carbon atoms, alkenyl having 2 to 5 carbon atoms, or alkynyl having 2 to 5 carbon atoms; Q represents oxygen or CH?; B represents CH?, C=O or CH-OH; R? represents hydrogen, alkyl having 1 to 6 carbon atoms, or R? and R? together optionally represent a carbon to carbon bond; or R? represents alkanoyl having 2 to 4 carbon atoms, carboxy, alkoxycarbonyl, or (CH?)y-CO?R? wherein y is 0 to 4 and R? is hydrogen or alkyl having 1 to 6 carbon atoms; and A represents-Z-CO?R? or-Z-COR?R1? wherein R? represents hydrogen or alkyl having 1 to 6 carbon atoms, R?, R1?, represent hydrogen, alkyl having 1 to 6 carbon atoms, or cycloalkyl having 3 to 6 carbon atoms or NR?R1? form a heterocyclic ring, and wherein Z is absent or represents straight or branched chain alkylene or alkenylene having up to 6 carbon atoms.These compounds are selective antagonists of leukotriene B?(LTB?) with little or no antagonism of leukotriene D? (LTD?) and are useful anti-inflammatory agents for treating inflammatory bowel disease, rheumatoid arthritis, gout and psoriasis.

Benzoic acid derivatives and their production

A benzoic acid derivative of the formula: STR1 wherein R1 stands for a lower alkyl group, R2 stands for an optionally protected carboxyl group and X stands for a halogen or a salt thereof, has excellent antiasthmatic and antiinflamma

Pharmaceutical compositions containing 4-carboxy-flavones

There are provided processes for preparing compounds of the formula: STR1 (wherein R1, R2, R3 and R4, which may be the same or different, each represent hydrogen, hydroxy, alkenyl, alkanoyl or alkyl, and X repre