2-<(4-bromo-2-fluorophenyl)methyl>-1,2,3,4-tetrahydro-4-(menthoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid 1,1-dimethylethyl ester

Base Information

Chemical Name:2-<(4-bromo-2-fluorophenyl)methyl>-1,2,3,4-tetrahydro-4-(menthoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid 1,1-dimethylethyl ester
CAS No.:129689-14-1
Molecular Formula:C₃₃H₃₉BrFNO₆
Molecular Weight:644.578
Hs Code.:

Synonyms:2-<(4-bromo-2-fluorophenyl)methyl>-1,2,3,4-tetrahydro-4-(menthoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid 1,1-dimethylethyl ester

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Chemical Property of 2-<(4-bromo-2-fluorophenyl)methyl>-1,2,3,4-tetrahydro-4-(menthoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid 1,1-dimethylethyl ester

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Technology Process of 2-<(4-bromo-2-fluorophenyl)methyl>-1,2,3,4-tetrahydro-4-(menthoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid 1,1-dimethylethyl ester

There total 4 articles about 2-<(4-bromo-2-fluorophenyl)methyl>-1,2,3,4-tetrahydro-4-(menthoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid 1,1-dimethylethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 5292-43-3
bromoacetic acid tert-butyl ester

: 2-<(4-bromo-2-fluorophenyl)methyl>-1,2,3,4-tetrahydro-1,3-dioxo-4-isoquinolinecarboxylic acid menthyl ester

: 129715-48-6
2-<(4-bromo-2-fluorophenyl)methyl>-1,2,3,4-tetrahydro-4-(menthoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid 1,1-dimethylethyl ester

: 129689-14-1
2-<(4-bromo-2-fluorophenyl)methyl>-1,2,3,4-tetrahydro-4-(menthoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid 1,1-dimethylethyl ester

Guidance literature:: With potassium carbonate; In N,N-dimethyl-formamide; at 85 ℃; for 2h;
DOI:10.1021/jm00039a017

Reference yield:

: 703-59-3
homophthalic anhydride

: 129689-14-1
2-<(4-bromo-2-fluorophenyl)methyl>-1,2,3,4-tetrahydro-4-(menthoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 3 steps

1: 51 percent / triethylamine / 1.) THF, RT, 1 h, 2.) DMF, reflux, 15 h

2: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 3 h, 2.) THF, RT, 30 min

3: 2.4 g / K₂CO₃ / dimethylformamide / 2 h / 85 °C

With potassium carbonate; triethylamine; lithium hexamethyldisilazane; In N,N-dimethyl-formamide;
DOI:10.1021/jm00039a017

Reference yield:

: 129688-66-0
2-<(4-bromo-2-fluorophenyl)methyl>-1,3,(2H,4H)-isoquinolinedione

: 129689-14-1
2-<(4-bromo-2-fluorophenyl)methyl>-1,2,3,4-tetrahydro-4-(menthoxycarbonyl)-1,3-dioxo-4-isoquinolineacetic acid 1,1-dimethylethyl ester

Guidance literature:: Multi-step reaction with 2 steps

1: 1.) lithium bis(trimethylsilyl)amide / 1.) THF, -78 deg C, 3 h, 2.) THF, RT, 30 min

2: 2.4 g / K₂CO₃ / dimethylformamide / 2 h / 85 °C

With potassium carbonate; lithium hexamethyldisilazane; In N,N-dimethyl-formamide;
DOI:10.1021/jm00039a017