(S)-t-butyl 3-(3-amino-4-(4-(t-butoxycarbonyl(4-methylpyridin-2-yl)amino)butoxy)phenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propanoate

Base Information

Chemical Name:(S)-t-butyl 3-(3-amino-4-(4-(t-butoxycarbonyl(4-methylpyridin-2-yl)amino)butoxy)phenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propanoate
CAS No.:1197191-62-0
Molecular Formula:C₃₅H₄₅F₃N₄O₇S
Molecular Weight:722.826
Hs Code.:

Synonyms:(S)-t-butyl 3-(3-amino-4-(4-(t-butoxycarbonyl(4-methylpyridin-2-yl)amino)butoxy)phenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propanoate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (S)-t-butyl 3-(3-amino-4-(4-(t-butoxycarbonyl(4-methylpyridin-2-yl)amino)butoxy)phenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propanoate

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Technology Process of (S)-t-butyl 3-(3-amino-4-(4-(t-butoxycarbonyl(4-methylpyridin-2-yl)amino)butoxy)phenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propanoate

There total 1 articles about (S)-t-butyl 3-(3-amino-4-(4-(t-butoxycarbonyl(4-methylpyridin-2-yl)amino)butoxy)phenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 89.0%

: 1197191-40-4
(S)-t-butyl 3-(4-(4-(t-butoxycarbonyl(4-methylpyridin-2-yl)amino)butoxy)-3-nitrophenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propanoate

: 1197191-62-0
(S)-t-butyl 3-(3-amino-4-(4-(t-butoxycarbonyl(4-methylpyridin-2-yl)amino)butoxy)phenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propanoate

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In methanol; at 20 ℃; for 18h; under 750.075 Torr;
DOI:10.1021/jm901133z

Reference yield: 62.0%

: 1197191-62-0
(S)-t-butyl 3-(3-amino-4-(4-(t-butoxycarbonyl(4-methylpyridin-2-yl)amino)butoxy)phenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propanoate

: 75-36-5
acetyl chloride

: 1197191-94-8
(S)-t-butyl 3-(3-acetamido-4-(4-(t-butoxycarbonyl(4-methylpyridin-2-yl)amino)butoxy)phenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propanoate

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 1.25h; Inert atmosphere;
DOI:10.1021/jm901133z

Reference yield: 61.0%

: 1197191-62-0
(S)-t-butyl 3-(3-amino-4-(4-(t-butoxycarbonyl(4-methylpyridin-2-yl)amino)butoxy)phenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propanoate

: 16024-60-5
3,6,9,12-tetraoxatridecanoic acid

: 1197191-82-4
(S)-t-butyl 3-(3-(2-(2-(2-(2-methoxyethoxy)ethoxy)ethoxy)acetamido)-4-(4-(4-methylpyridin-2-yl-t-butoxycarbonylamino)butoxy)phenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propanoate

Guidance literature:: 3,6,9,12-tetraoxatridecanoic acid; With benzotriazol-1-yloxyl-tris-(pyrrolidino)-phosphonium hexafluorophosphate; triethylamine; In N,N-dimethyl-formamide; at 20 ℃; for 2h; Inert atmosphere;

(S)-t-butyl 3-(3-amino-4-(4-(t-butoxycarbonyl(4-methylpyridin-2-yl)amino)butoxy)phenyl)-2-(3-(trifluoromethyl)phenylsulfonamido)propanoate; In N,N-dimethyl-formamide; at 20 ℃; for 18h;
DOI:10.1021/jm901133z