1-[1-(3-amino-benzyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl]-3-phenyl-urea

Base Information

Chemical Name:1-[1-(3-amino-benzyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl]-3-phenyl-urea
CAS No.:211760-27-9
Molecular Formula:C₂₄H₂₄N₄O₂
Molecular Weight:400.48
Hs Code.:

1-[1-(3-amino-benzyl)-2-oxo-2,3,4,5-tetrahydro-1<i>H</i>-benzo[<i>b</i>]azepin-3-yl]-3-phenyl-urea

Synonyms:1-[1-(3-amino-benzyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl]-3-phenyl-urea

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Chemical Property of 1-[1-(3-amino-benzyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl]-3-phenyl-urea

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Technology Process of 1-[1-(3-amino-benzyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl]-3-phenyl-urea

There total 6 articles about 1-[1-(3-amino-benzyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl]-3-phenyl-urea which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

: 211760-04-2
{3-[2-oxo-3-(3-phenyl-ureido)-2,3,4,5-tetrahydro-benzo[b]azepin-1-ylmethyl]-phenyl}-carbamic acid tert-butyl ester

: 211760-27-9
1-[1-(3-amino-benzyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl]-3-phenyl-urea

Guidance literature:: With methoxybenzene; trifluoroacetic acid; In dichloromethane; for 3h; Ambient temperature;
DOI:10.1021/jm990044m

Reference yield:

: 97278-68-7,86499-24-3
3-azido-2,3,4,5-tetrahydro-2-oxo-1 H-1-benzazepine

: 211760-27-9
1-[1-(3-amino-benzyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl]-3-phenyl-urea

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / tetra-n-butylammonium bromide, KOH / tetrahydrofuran / 2 h / Ambient temperature

2: 100 percent / H₂ / 10 percent Pd/C / methanol / Ambient temperature

3: 70 percent / dimethylformamide / Ambient temperature

4: 100 percent / trifluoroacetic acid, anisole / CH₂Cl₂ / 3 h / Ambient temperature

With potassium hydroxide; tetrabutylammomium bromide; hydrogen; methoxybenzene; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm990044m

Reference yield:

: 118684-32-5
[3-[N-(tert-butoxycarbonyl)amino]phenyl]methyl bromide

: 211760-27-9
1-[1-(3-amino-benzyl)-2-oxo-2,3,4,5-tetrahydro-1H-benzo[b]azepin-3-yl]-3-phenyl-urea

Guidance literature:: Multi-step reaction with 4 steps

1: 96 percent / tetra-n-butylammonium bromide, KOH / tetrahydrofuran / 2 h / Ambient temperature

2: 100 percent / H₂ / 10 percent Pd/C / methanol / Ambient temperature

3: 70 percent / dimethylformamide / Ambient temperature

4: 100 percent / trifluoroacetic acid, anisole / CH₂Cl₂ / 3 h / Ambient temperature

With potassium hydroxide; tetrabutylammomium bromide; hydrogen; methoxybenzene; trifluoroacetic acid; palladium on activated charcoal; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide;
DOI:10.1021/jm990044m