1,1,1,3,3,3-hexafluoro-2-(4-(2-((2-methoxy-3-pyridinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

Base Information

• Chemical Name: 1,1,1,3,3,3-hexafluoro-2-(4-(2-((2-methoxy-3-pyridinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol
• CAS No.: 1361225-04-8
• Molecular Formula: C₂₄H₂₃F₆N₃O₄S₂
• Molecular Weight: 595.587
• Mol file: 1361225-04-8.mol

Synonyms:1,1,1,3,3,3-hexafluoro-2-(4-(2-((2-methoxy-3-pyridinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

Chemical Property of 1,1,1,3,3,3-hexafluoro-2-(4-(2-((2-methoxy-3-pyridinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 1,1,1,3,3,3-hexafluoro-2-(4-(2-((2-methoxy-3-pyridinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol

There total 10 articles about 1,1,1,3,3,3-hexafluoro-2-(4-(2-((2-methoxy-3-pyridinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

3-((2-methoxy-3-pyridinyl)methyl)-1-(2-thiophenylsulfonyl)piperazine (1361225-11-7) + 2-(4-bromophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol (2402-72-4) → 1,1,1,3,3,3-hexafluoro-2-(4-(2-((2-methoxy-3-pyridinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol (1361225-04-8)

Guidance literature:

With sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos; In toluene; at 100 ℃; for 18h;

Reference yield:

2-methoxynicotinic acid (16498-81-0) → 1,1,1,3,3,3-hexafluoro-2-(4-(2-((2-methoxy-3-pyridinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol (1361225-04-8)

Guidance literature:

Multi-step reaction with 10 steps

1.1: dimethylsulfide borane complex / tetrahydrofuran / 16 h / 70 °C

1.2: 0.33 h / 0 °C

2.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 3 h / 20 °C

3.1: sodium hydroxide / tetrahydrofuran / 24 h / 20 °C

4.1: hydrogenchloride; water / tetrahydrofuran / 1 h / 0 °C

5.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

6.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

7.1: N-ethyl-N,N-diisopropylamine / methanol / 36 h / 70 °C

8.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 70 °C

8.2: 0.33 h / 20 °C

9.1: triethylamine / dichloromethane / 1 h / 0 °C

10.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos / toluene / 18 h / 100 °C

With hydrogenchloride; carbon tetrabromide; dimethylsulfide borane complex; water; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; sodium hydroxide; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

Reference yield:

(2-methoxy-pyridin-3-yl)-methanol (112197-16-7) → 1,1,1,3,3,3-hexafluoro-2-(4-(2-((2-methoxy-3-pyridinyl)methyl)-4-(2-thiophenylsulfonyl)-1-piperazinyl)phenyl)-2-propanol (1361225-04-8)

Guidance literature:

Multi-step reaction with 9 steps

1.1: carbon tetrabromide; triphenylphosphine / dichloromethane / 3 h / 20 °C

2.1: sodium hydroxide / tetrahydrofuran / 24 h / 20 °C

3.1: hydrogenchloride; water / tetrahydrofuran / 1 h / 0 °C

4.1: N-ethyl-N,N-diisopropylamine; HATU / N,N-dimethyl-formamide / 16 h / 20 °C

5.1: trifluoroacetic acid / dichloromethane / 2 h / 20 °C

6.1: N-ethyl-N,N-diisopropylamine / methanol / 36 h / 70 °C

7.1: dimethylsulfide borane complex / tetrahydrofuran / 2 h / 70 °C

7.2: 0.33 h / 20 °C

8.1: triethylamine / dichloromethane / 1 h / 0 °C

9.1: sodium t-butanolate / tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos / toluene / 18 h / 100 °C

With hydrogenchloride; carbon tetrabromide; dimethylsulfide borane complex; water; triethylamine; N-ethyl-N,N-diisopropylamine; triphenylphosphine; HATU; trifluoroacetic acid; sodium hydroxide; sodium t-butanolate; tris-(dibenzylideneacetone)dipalladium⁽⁰⁾; ruphos; In tetrahydrofuran; methanol; dichloromethane; N,N-dimethyl-formamide; toluene;

upstream raw materials:

3-((2-methoxy-3-pyridinyl)methyl)-1-(2-thiophenylsulfonyl)piperazine

2-(4-bromophenyl)-1,1,1,3,3,3-hexafluoro-2-propanol

(2-methoxy-pyridin-3-yl)-methanol

2-methoxynicotinic acid