tert-butyl-N-((tert-butoxy)carbonyl)-N-(2-fluoro-5-nitrophenyl)carbamate

Base Information

• Chemical Name: tert-butyl-N-((tert-butoxy)carbonyl)-N-(2-fluoro-5-nitrophenyl)carbamate
• CAS No.: 1125632-86-1
• Molecular Formula: C₁₆H₂₁FN₂O₆
• Molecular Weight: 356.351

Synonyms:tert-butyl-N-((tert-butoxy)carbonyl)-N-(2-fluoro-5-nitrophenyl)carbamate

Chemical Property of tert-butyl-N-((tert-butoxy)carbonyl)-N-(2-fluoro-5-nitrophenyl)carbamate

Chemical Property:

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Technology Process of tert-butyl-N-((tert-butoxy)carbonyl)-N-(2-fluoro-5-nitrophenyl)carbamate

There total 3 articles about tert-butyl-N-((tert-butoxy)carbonyl)-N-(2-fluoro-5-nitrophenyl)carbamate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 72.0%

di-tert-butyl dicarbonate (24424-99-5) + 6-fluoro-3-nitroaniline (369-36-8) → tert-butyl-N-((tert-butoxy)carbonyl)-N-(2-fluoro-5-nitrophenyl)carbamate (1125632-86-1)

Guidance literature:

With triethylamine; In dichloromethane; at 55 ℃; for 12h;

DOI:10.1016/j.bmc.2012.07.032

Reference yield: 20.0%

→ tert-butyl-N-((tert-butoxy)carbonyl)-N-(2-fluoro-5-nitrophenyl)carbamate (1125632-86-1) + tert-butyl (2-fluoro-5-nitrophenyl)carbamate (535170-15-1)

Guidance literature:

With dmap; In dichloromethane; at 20 ℃; for 72h;

Reference yield:

di-tert-butyl dicarbonate (24424-99-5) + 6-fluoro-3-nitroaniline (369-36-8) → tert-butyl-N-((tert-butoxy)carbonyl)-N-(2-fluoro-5-nitrophenyl)carbamate (1125632-86-1) + tert-butyl (2-fluoro-5-nitrophenyl)carbamate (535170-15-1)

Guidance literature:

at 80 ℃; for 24h;

DOI:10.1016/j.bmc.2012.07.032

upstream raw materials:

di-tert-butyl dicarbonate

6-fluoro-3-nitroaniline

Downstream raw materials:

N-(5-{[4-fluoro-3-({[4-(trifluoromethoxy)phenyl]carbamoyl}amino)phenyl]amino}[1,3]thi azolo[5,4-b]pyridin-2-yl)cyclopropanecarboxamide

tert-butyl N-((tert-butoxy)carbonyl)-(5-amino-2-fluorophenyl)carbamate

tert-butyl [5-({2-[(cyclopropylcarbonyl)amino][1,3]thiazolo[5,4-b]pyridin-5-yl}amino)-2-fluorophenyl]carbamate

N-{5-[(3-amino-4-fluorophenyl)amino][1,3]thiazolo[5,4-b]pyridin-2-yl}cyclopropanecarboxamide

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