2-fluoro-N-(((2S,8R,9R)-11-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-2,9-dimethyl-12-oxo-14-(3-phenylureudo)-2,3,4,5,6,8,9,10,11,12-decahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-8-yl)methyl)-N-methylbenzenesulfonamide

Base Information

Chemical Name:2-fluoro-N-(((2S,8R,9R)-11-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-2,9-dimethyl-12-oxo-14-(3-phenylureudo)-2,3,4,5,6,8,9,10,11,12-decahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-8-yl)methyl)-N-methylbenzenesulfonamide
CAS No.:1353557-47-7
Molecular Formula:C₄₃H₅₃FN₄O₈S
Molecular Weight:804.98
Hs Code.:

2-fluoro-N-(((2S,8R,9R)-11-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-2,9-dimethyl-12-oxo-14-(3-phenylureudo)-2,3,4,5,6,8,9,10,11,12-decahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-8-yl)methyl)-N-methylbenzenesulfonamide

Synonyms:2-fluoro-N-(((2S,8R,9R)-11-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-2,9-dimethyl-12-oxo-14-(3-phenylureudo)-2,3,4,5,6,8,9,10,11,12-decahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-8-yl)methyl)-N-methylbenzenesulfonamide

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Chemical Property of 2-fluoro-N-(((2S,8R,9R)-11-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-2,9-dimethyl-12-oxo-14-(3-phenylureudo)-2,3,4,5,6,8,9,10,11,12-decahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-8-yl)methyl)-N-methylbenzenesulfonamide

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Technology Process of 2-fluoro-N-(((2S,8R,9R)-11-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-2,9-dimethyl-12-oxo-14-(3-phenylureudo)-2,3,4,5,6,8,9,10,11,12-decahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-8-yl)methyl)-N-methylbenzenesulfonamide

There total 10 articles about 2-fluoro-N-(((2S,8R,9R)-11-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-2,9-dimethyl-12-oxo-14-(3-phenylureudo)-2,3,4,5,6,8,9,10,11,12-decahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-8-yl)methyl)-N-methylbenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 349-88-2
4-Fluorobenzenesulfonyl chloride

: 1353557-67-1
C₃₇H₅₀N₄O₆

: 1353557-47-7
2-fluoro-N-(((2S,8R,9R)-11-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-2,9-dimethyl-12-oxo-14-(3-phenylureudo)-2,3,4,5,6,8,9,10,11,12-decahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-8-yl)methyl)-N-methylbenzenesulfonamide

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 20 ℃; Inert atmosphere;
DOI:10.1021/ml200244k

Reference yield:

: 1333331-66-0
tert-butyl (((2S,8R,9R)-14-amino-11-((S)-1-((4-methoxybenzyloxy)prop-2-yl)-2,9-dimethyl-12-oxo-2,3,4,5,6,8,9,10,11,12-ecahydrobenzo[b][1,9,5]dioxaazacyclotetradec-8-yl)methyl)-methyl)carbamate

: 1353557-47-7
2-fluoro-N-(((2S,8R,9R)-11-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-2,9-dimethyl-12-oxo-14-(3-phenylureudo)-2,3,4,5,6,8,9,10,11,12-decahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-8-yl)methyl)-N-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: dichloromethane / 16 h / Inert atmosphere

2.1: 2,6-dimethylpyridine; t-butyldimethylsiyl triflate / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere

2.2: 0.5 h

3.1: 2,6-dimethylpyridine / dichloromethane / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; t-butyldimethylsiyl triflate; In dichloromethane;
DOI:10.1021/ml200244k

Reference yield:

: 1353557-64-8
tert-butyl (((2S,8R,9R)-11-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-2,9-dimethyl-12-oxo-14-(3-phenylureido)-2,3,4,5,6,8,9,10,11,12-decahydrobenzo[b][1.9.5]dioxaazacyclotetradecin-8-yl)methyl)(methyl)carbamate

: 1353557-47-7
2-fluoro-N-(((2S,8R,9R)-11-((S)-1-((4-methoxybenzyl)oxy)propan-2-yl)-2,9-dimethyl-12-oxo-14-(3-phenylureudo)-2,3,4,5,6,8,9,10,11,12-decahydrobenzo[b][1,9,5]dioxaazacyclotetradecin-8-yl)methyl)-N-methylbenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: 2,6-dimethylpyridine; t-butyldimethylsiyl triflate / dichloromethane / 3.5 h / 0 - 20 °C / Inert atmosphere

1.2: 0.5 h

2.1: 2,6-dimethylpyridine / dichloromethane / 20 °C / Inert atmosphere

With 2,6-dimethylpyridine; t-butyldimethylsiyl triflate; In dichloromethane;
DOI:10.1021/ml200244k