1-(1-naphthyloxyacetyl)-4-(4-tolyloxyacetyl)thiosemicarbazide

Base Information

• Chemical Name: 1-(1-naphthyloxyacetyl)-4-(4-tolyloxyacetyl)thiosemicarbazide
• CAS No.: 337919-47-8
• Molecular Formula: C₂₂H₂₁N₃O₄S
• Molecular Weight: 423.492
• Mol file: 337919-47-8.mol

Synonyms:1-(1-naphthyloxyacetyl)-4-(4-tolyloxyacetyl)thiosemicarbazide

Chemical Property of 1-(1-naphthyloxyacetyl)-4-(4-tolyloxyacetyl)thiosemicarbazide

Chemical Property:

Purity/Quality:

Safty Information:

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MSDS Files:

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Technology Process of 1-(1-naphthyloxyacetyl)-4-(4-tolyloxyacetyl)thiosemicarbazide

There total 2 articles about 1-(1-naphthyloxyacetyl)-4-(4-tolyloxyacetyl)thiosemicarbazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 88.0%

α-naphthoxyacetylhydrazine (24310-15-4) + 4-tolyloxyacetyl isothiocyanate → 1-(1-naphthyloxyacetyl)-4-(4-tolyloxyacetyl)thiosemicarbazide (337919-47-8)

Guidance literature:

In dichloromethane; at 20 ℃; for 0.5h;

DOI:10.1081/SCC-100000174

Reference yield:

2-(4-methylphenoxy)acetyl chloride (15516-47-9) → 1-(1-naphthyloxyacetyl)-4-(4-tolyloxyacetyl)thiosemicarbazide (337919-47-8)

Guidance literature:

Multi-step reaction with 2 steps

1: polyethylene glycol-400 / CH₂Cl₂ / 1 h / 20 °C

2: 88 percent / CH₂Cl₂ / 0.5 h / 20 °C

With polyethylene glycol-400; In dichloromethane;

DOI:10.1081/SCC-100000174

Reference yield: 97.0%

1-(1-naphthyloxyacetyl)-4-(4-tolyloxyacetyl)thiosemicarbazide (337919-47-8) → 2-(4-tolyloxyacetylamino)-5-(1-naphthyloxymethyl)-1,3,4-thiadiazole

Guidance literature:

With acetic acid; for 0.0833333h; microwave irradiation;

DOI:10.1081/SCC-100000174

upstream raw materials:

α-naphthoxyacetylhydrazine

2-(4-methylphenoxy)acetyl chloride