2-(1-Naphthyloxy)acetohydrazide

Base Information

• Chemical Name: 2-(1-Naphthyloxy)acetohydrazide
• CAS No.: 24310-15-4
• Molecular Formula: C12H12 N2 O2
• Molecular Weight: 216.239
• Hs Code.: 2928000090
• European Community (EC) Number: 672-247-8
• DSSTox Substance ID: DTXSID90352585
• Wikidata: Q82129820
• ChEMBL ID: CHEMBL4437797
• Mol file: 24310-15-4.mol

Synonyms:24310-15-4;2-(1-naphthyloxy)acetohydrazide;1-(Naphthoxy)acetic acid hydrazide;2-(naphthalen-1-yloxy)acetohydrazide;2-naphthalen-1-yloxyacetohydrazide;2-(naphthoxy)acetic acid hydrazide;CBMicro_020281;Oprea1_049576;Oprea1_050479;naphthoxy acetic acid hydrazide;SCHEMBL4302000;CHEMBL4437797;DTXSID90352585;BDBM163686;CCG-8044;BBL002019;MFCD00156157;STK085668;AKOS000267170;SB86188;UPCMLD0ENAT5559088:001;BIM-0020174.P001;Aceticacid,2-(1-naphthalenyloxy)-,hydrazide;CS-0204508;FT-0638411;AB00084062-01;A817212;SR-01000207916;10R-1242;SR-01000207916-1;Z57204347;2‐(Naphthalen‐1‐yloxy)acetohydrazide (040)

Chemical Property of 2-(1-Naphthyloxy)acetohydrazide

Chemical Property:

• Vapor Pressure: 1.06E-09mmHg at 25°C
• Boiling Point: 488.7°C at 760 mmHg
• PKA: 12.23±0.35(Predicted)
• Flash Point: 249.4°C
• PSA: 64.35000
• Density: 1.245g/cm³
• LogP: 2.29970
• XLogP3: 1.8
• Hydrogen Bond Donor Count: 2
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 216.089877630
• Heavy Atom Count: 16
• Complexity: 245

Purity/Quality:

98%min ^*data from raw suppliers

2-(1-Naphthyloxy)acetohydrazide ^*data from reagent suppliers

Safty Information:

• Pictogram(s): Xi
• Hazard Codes: Xi

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC=C2C(=C1)C=CC=C2OCC(=O)NN

Technology Process of 2-(1-Naphthyloxy)acetohydrazide

There total 5 articles about 2-(1-Naphthyloxy)acetohydrazide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

ethyl (1-naphthalenyloxy)acetate (41643-81-6) → α-naphthoxyacetylhydrazine (24310-15-4)

Guidance literature:

With hydrazine hydrate; In ethanol; at 20 ℃; for 4h;

DOI:10.1016/j.bmcl.2020.127743

Reference yield:

1-Naphthoxyacetic acid (2976-75-2) → α-naphthoxyacetylhydrazine (24310-15-4)

Guidance literature:

Multi-step reaction with 2 steps

1: H₂SO₄ / 3 h / Heating

2: hydrazine hydrate / ethanol / 14 h / Heating

With sulfuric acid; hydrazine hydrate; In ethanol;

Reference yield:

α-naphthol (90-15-3) → α-naphthoxyacetylhydrazine (24310-15-4)

Guidance literature:

Multi-step reaction with 2 steps

1: K₂CO₃ / acetone

2: hydrazine hydrate / ethanol / Heating

With potassium carbonate; hydrazine hydrate; In ethanol; acetone;

DOI:10.1016/S0014-827X(02)01245-4

upstream raw materials:

ethyl (1-naphthalenyloxy)acetate

1-Naphthoxyacetic acid

α-naphthol

Downstream raw materials:

5-(α-Naphthoxymethyl)-2-amino-1,3,4-oxdiazol

5-(p-chlorophenyl)-1-(α-naphthyloxyacetyl)-5-hydroxy-3-(5-nitro-2-furyl)pyrazoline

1-(1-naphthyloxyacetyl)-4-(5-(2-chlorophenyl)-2-furoyl)-thiosemicarbazide

C₁₉H₁₆ClN₃O₂S

Refernces

• 1、 Desai,Pandya, Darshan,Vaja, Darshita. "Synthesis and antimicrobial activity of some heterocyclic compounds bearing benzimidazole and pyrazoline motifs". . p. 52 - 60. Retrieved 2018.
• 2、 Kashyap, Kumari Somlata,Kumar, Ashish,Hira, Sumit Kumar,Dey, Swapan. "Recognition of Al3+ through the off-on mechanism as a proficient driving force for the hydrolysis of BODIPY conjugated Schiff base and its application in bio-imaging". . . Retrieved 2019/10/04.