N-(4-methoxyphenyl)-5-methyl-1-phenyl-1H-1,2,3-triazole-4-carboxamide

Base Information

• Chemical Name: N-(4-methoxyphenyl)-5-methyl-1-phenyl-1H-1,2,3-triazole-4-carboxamide
• CAS No.: 866871-78-5
• Molecular Formula: C₁₇H₁₆N₄O₂
• Molecular Weight: 308.34
• Mol file: 866871-78-5.mol

Synonyms:N-(4-methoxyphenyl)-5-methyl-1-phenyl-1H-1,2,3-triazole-4-carboxamide

Chemical Property of N-(4-methoxyphenyl)-5-methyl-1-phenyl-1H-1,2,3-triazole-4-carboxamide

Chemical Property:

Purity/Quality:

99% ^*data from raw suppliers

N-(4-methoxyphenyl)-5-methyl-1-phenyl-1H-1,2,3-triazole-4-carboxamide ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of N-(4-methoxyphenyl)-5-methyl-1-phenyl-1H-1,2,3-triazole-4-carboxamide

There total 3 articles about N-(4-methoxyphenyl)-5-methyl-1-phenyl-1H-1,2,3-triazole-4-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

4'-methoxyacetoacetanilide (5437-98-9) + Phenyl azide (622-37-7) → N-(4-methoxyphenyl)-5-methyl-1-phenyl-1H-1,2,3-triazole-4-carboxamide (866871-78-5)

Guidance literature:

With diethylamine; In dimethyl sulfoxide; at 20 ℃; for 0.25h; Sonication;

DOI:10.1016/j.ultsonch.2016.05.007

Reference yield: 86.0%

2-diazo-N-(4-methoxyphenyl)-3-oxobutanamide (1384290-41-8) + aniline (62-53-3) → N-(4-methoxyphenyl)-5-methyl-1-phenyl-1H-1,2,3-triazole-4-carboxamide (866871-78-5)

Guidance literature:

With iron(II) chloride; In N,N-dimethyl-formamide; at 80 ℃; for 10h; regiospecific reaction;

DOI:10.1039/c2cc33157h

Reference yield:

4'-methoxyacetoacetanilide (5437-98-9) → N-(4-methoxyphenyl)-5-methyl-1-phenyl-1H-1,2,3-triazole-4-carboxamide (866871-78-5)

Guidance literature:

Multi-step reaction with 2 steps

1: 4-toluenesulfonyl azide; triethylamine / acetonitrile / 12 h / 20 °C

2: iron(II) chloride / N,N-dimethyl-formamide / 10 h / 80 °C

With 4-toluenesulfonyl azide; triethylamine; iron(II) chloride; In N,N-dimethyl-formamide; acetonitrile; 2: Wolff cyclocondensation;

DOI:10.1039/c2cc33157h

upstream raw materials:

2-diazo-N-(4-methoxyphenyl)-3-oxobutanamide

aniline

4'-methoxyacetoacetanilide

Phenyl azide