N-[4-acetyl-1-(4-fluorophenyl)-5-methyl-2-oxo-3-trifluoromethyl-2,3-dihydro-1H-pyrrole-3-yl]-4-acetamidobenzenesulfonamide

Base Information

Chemical Name:N-[4-acetyl-1-(4-fluorophenyl)-5-methyl-2-oxo-3-trifluoromethyl-2,3-dihydro-1H-pyrrole-3-yl]-4-acetamidobenzenesulfonamide
CAS No.:704874-83-9
Molecular Formula:C₂₂H₁₉F₄N₃O₅S
Molecular Weight:513.47
Hs Code.:

Synonyms:N-[4-acetyl-1-(4-fluorophenyl)-5-methyl-2-oxo-3-trifluoromethyl-2,3-dihydro-1H-pyrrole-3-yl]-4-acetamidobenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[4-acetyl-1-(4-fluorophenyl)-5-methyl-2-oxo-3-trifluoromethyl-2,3-dihydro-1H-pyrrole-3-yl]-4-acetamidobenzenesulfonamide

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Technology Process of N-[4-acetyl-1-(4-fluorophenyl)-5-methyl-2-oxo-3-trifluoromethyl-2,3-dihydro-1H-pyrrole-3-yl]-4-acetamidobenzenesulfonamide

There total 2 articles about N-[4-acetyl-1-(4-fluorophenyl)-5-methyl-2-oxo-3-trifluoromethyl-2,3-dihydro-1H-pyrrole-3-yl]-4-acetamidobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: methyl 2-[4-(N-acetylamino)benzenesulfonylimino]-3,3,3-trifluoropropionate

: 1978-63-8
4-(4-fluoroanilino)pent-3-en-2-one

: 704874-83-9
N-[4-acetyl-1-(4-fluorophenyl)-5-methyl-2-oxo-3-trifluoromethyl-2,3-dihydro-1H-pyrrole-3-yl]-4-acetamidobenzenesulfonamide

Guidance literature:: With triethylamine; In N,N-dimethyl-formamide; at 20 - 100 ℃; for 3h;
DOI:10.1007/s11172-010-0061-z

Reference yield:

: 121-61-9
p-acetylaminobenzenesulfonamide

: 704874-83-9
N-[4-acetyl-1-(4-fluorophenyl)-5-methyl-2-oxo-3-trifluoromethyl-2,3-dihydro-1H-pyrrole-3-yl]-4-acetamidobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: pyridine / N,N-dimethyl-formamide / 0.5 h

1.2: 1 h

2.1: triethylamine / N,N-dimethyl-formamide / 3 h / 20 - 100 °C

With pyridine; triethylamine; In N,N-dimethyl-formamide;
DOI:10.1007/s11172-010-0061-z

Reference yield: 91.0%

: 704874-83-9
N-[4-acetyl-1-(4-fluorophenyl)-5-methyl-2-oxo-3-trifluoromethyl-2,3-dihydro-1H-pyrrole-3-yl]-4-acetamidobenzenesulfonamide

: 1240506-39-1
N-[4-acetyl-1-(4-fluorophenyl)-5-methyl-2-oxo-3-trifluoromethyl-2,3-dihydro-1H-pyrrole-3-yl]-4-aminobenzenesulfonamide

Guidance literature:: N-[4-acetyl-1-(4-fluorophenyl)-5-methyl-2-oxo-3-trifluoromethyl-2,3-dihydro-1H-pyrrole-3-yl]-4-acetamidobenzenesulfonamide; With hydrogenchloride; In water; for 1h; Reflux;

With ammonia; In water;
DOI:10.1007/s11172-010-0061-z