N-[4-acetyl-1-(4-fluorophenyl)-5-methyl-2-oxo-3-trifluoromethyl-2,3-dihydro-1H-pyrrole-3-yl]-4-aminobenzenesulfonamide

Base Information

Chemical Name:N-[4-acetyl-1-(4-fluorophenyl)-5-methyl-2-oxo-3-trifluoromethyl-2,3-dihydro-1H-pyrrole-3-yl]-4-aminobenzenesulfonamide
CAS No.:1240506-39-1
Molecular Formula:C₂₀H₁₇F₄N₃O₄S
Molecular Weight:471.432
Hs Code.:

Synonyms:N-[4-acetyl-1-(4-fluorophenyl)-5-methyl-2-oxo-3-trifluoromethyl-2,3-dihydro-1H-pyrrole-3-yl]-4-aminobenzenesulfonamide

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of N-[4-acetyl-1-(4-fluorophenyl)-5-methyl-2-oxo-3-trifluoromethyl-2,3-dihydro-1H-pyrrole-3-yl]-4-aminobenzenesulfonamide

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Technology Process of N-[4-acetyl-1-(4-fluorophenyl)-5-methyl-2-oxo-3-trifluoromethyl-2,3-dihydro-1H-pyrrole-3-yl]-4-aminobenzenesulfonamide

There total 3 articles about N-[4-acetyl-1-(4-fluorophenyl)-5-methyl-2-oxo-3-trifluoromethyl-2,3-dihydro-1H-pyrrole-3-yl]-4-aminobenzenesulfonamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 704874-83-9
N-[4-acetyl-1-(4-fluorophenyl)-5-methyl-2-oxo-3-trifluoromethyl-2,3-dihydro-1H-pyrrole-3-yl]-4-acetamidobenzenesulfonamide

: 1240506-39-1
N-[4-acetyl-1-(4-fluorophenyl)-5-methyl-2-oxo-3-trifluoromethyl-2,3-dihydro-1H-pyrrole-3-yl]-4-aminobenzenesulfonamide

Guidance literature:: N-[4-acetyl-1-(4-fluorophenyl)-5-methyl-2-oxo-3-trifluoromethyl-2,3-dihydro-1H-pyrrole-3-yl]-4-acetamidobenzenesulfonamide; With hydrogenchloride; In water; for 1h; Reflux;

With ammonia; In water;
DOI:10.1007/s11172-010-0061-z

Reference yield:

: methyl 2-[4-(N-acetylamino)benzenesulfonylimino]-3,3,3-trifluoropropionate

: 1240506-39-1
N-[4-acetyl-1-(4-fluorophenyl)-5-methyl-2-oxo-3-trifluoromethyl-2,3-dihydro-1H-pyrrole-3-yl]-4-aminobenzenesulfonamide

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / N,N-dimethyl-formamide / 3 h / 20 - 100 °C

2: hydrogenchloride / water / 1 h / Reflux

With hydrogenchloride; triethylamine; In water; N,N-dimethyl-formamide;
DOI:10.1007/s11172-010-0061-z

Reference yield:

: 121-61-9
p-acetylaminobenzenesulfonamide

: 1240506-39-1
N-[4-acetyl-1-(4-fluorophenyl)-5-methyl-2-oxo-3-trifluoromethyl-2,3-dihydro-1H-pyrrole-3-yl]-4-aminobenzenesulfonamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: pyridine / N,N-dimethyl-formamide / 0.5 h

1.2: 1 h

2.1: triethylamine / N,N-dimethyl-formamide / 3 h / 20 - 100 °C

3.1: hydrogenchloride / water / 1 h / Reflux

With pyridine; hydrogenchloride; triethylamine; In water; N,N-dimethyl-formamide;
DOI:10.1007/s11172-010-0061-z