2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)-1,5-naphthyridine

Base Information

Chemical Name:2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)-1,5-naphthyridine
CAS No.:1521139-22-9
Molecular Formula:C₂₅H₂₀FN₅O
Molecular Weight:425.465
Hs Code.:

Synonyms:2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)-1,5-naphthyridine

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Chemical Property of 2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)-1,5-naphthyridine

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Technology Process of 2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)-1,5-naphthyridine

There total 9 articles about 2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)-1,5-naphthyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 1301167-65-6
4-[1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl]phenol

: 1083181-29-6
2-(chloromethyl)-1,5-naphthyridine

: 1521139-22-9
2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)-1,5-naphthyridine

Guidance literature:: 4-[1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl]phenol; With sodium hexamethyldisilazane; In tetrahydrofuran; N,N-dimethyl-formamide; at 0 ℃; for 0.0833333h; Inert atmosphere;

2-(chloromethyl)-1,5-naphthyridine; In tetrahydrofuran; N,N-dimethyl-formamide; at 20 ℃; for 2h;

Reference yield:

: 7675-32-3
2-methyl-[1,5]naphthyridine

: 1521139-22-9
2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)-1,5-naphthyridine

Guidance literature:: Multi-step reaction with 2 steps

1.1: dibenzoyl peroxide; N-chloro-succinimide / tetrachloromethane / 17 h / Reflux

2.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.08 h / 0 °C / Inert atmosphere

2.2: 2 h / 20 °C

With N-chloro-succinimide; sodium hexamethyldisilazane; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; N,N-dimethyl-formamide;

Reference yield:

: 1521138-31-7
2-(3-(4-(benzyloxy)phenyl)-4-(pyridin-4-yl)-1H-pyrazol-1-yl)ethyl methanesulfonate

: 1521139-22-9
2-((4-(1-(2-fluoroethyl)-4-(pyridin-4-yl)-1H-pyrazol-3-yl)phenoxy)methyl)-1,5-naphthyridine

Guidance literature:: Multi-step reaction with 3 steps

1.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 20 °C

2.1: palladium on activated charcoal; hydrogen / ethanol; ethyl acetate / 18 h / 1900.13 Torr / Autoclave

3.1: sodium hexamethyldisilazane / tetrahydrofuran; N,N-dimethyl-formamide / 0.08 h / 0 °C / Inert atmosphere

3.2: 2 h / 20 °C

With palladium on activated charcoal; tetrabutyl ammonium fluoride; hydrogen; sodium hexamethyldisilazane; In tetrahydrofuran; ethanol; ethyl acetate; N,N-dimethyl-formamide;