(S)-methyl 2-((S)-2-(2-((Z)-2-fluoro2-(3-(pyrimidin-5-yl)phenyl)vinyl)benzamido)-3-phenylpropanamido)-3-methylbutanoate

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Chemical Name:(S)-methyl 2-((S)-2-(2-((Z)-2-fluoro2-(3-(pyrimidin-5-yl)phenyl)vinyl)benzamido)-3-phenylpropanamido)-3-methylbutanoate
CAS No.:1206904-60-0
Molecular Formula:C₃₄H₃₃FN₄O₄
Molecular Weight:580.659
Hs Code.:

Synonyms:(S)-methyl 2-((S)-2-(2-((Z)-2-fluoro2-(3-(pyrimidin-5-yl)phenyl)vinyl)benzamido)-3-phenylpropanamido)-3-methylbutanoate

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Chemical Property of (S)-methyl 2-((S)-2-(2-((Z)-2-fluoro2-(3-(pyrimidin-5-yl)phenyl)vinyl)benzamido)-3-phenylpropanamido)-3-methylbutanoate

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Technology Process of (S)-methyl 2-((S)-2-(2-((Z)-2-fluoro2-(3-(pyrimidin-5-yl)phenyl)vinyl)benzamido)-3-phenylpropanamido)-3-methylbutanoate

There total 2 articles about (S)-methyl 2-((S)-2-(2-((Z)-2-fluoro2-(3-(pyrimidin-5-yl)phenyl)vinyl)benzamido)-3-phenylpropanamido)-3-methylbutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 78.0%

: 1206904-80-4
(Z)-5-(3-(2-bromo-1-fluorovinyl)phenyl)pyrimidine

: 1206904-59-7
(S)-methyl 3-methyl-2-((S)-3-phenyl-2-(2-(tributylstannyl)benzamido)propanamido)butanoate

: 1206904-60-0
(S)-methyl 2-((S)-2-(2-((Z)-2-fluoro2-(3-(pyrimidin-5-yl)phenyl)vinyl)benzamido)-3-phenylpropanamido)-3-methylbutanoate

Guidance literature:: With (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; In tetrahydrofuran; toluene; at 70 ℃; for 10h; Inert atmosphere;
DOI:10.1016/j.tetlet.2009.10.099

Reference yield: 78.0%

: C₁₉H₁₃FN₂O₂

: 80870-38-8
(S)-methyl 2-((S)-2-amino-3-phenylpropanamido)-3-methylbutanoate

: 1206904-60-0
(S)-methyl 2-((S)-2-(2-((Z)-2-fluoro2-(3-(pyrimidin-5-yl)phenyl)vinyl)benzamido)-3-phenylpropanamido)-3-methylbutanoate

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; acetonitrile; for 12h; Inert atmosphere;
DOI:10.1016/j.tetlet.2009.10.099