ethyl (R)-7-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-7-oxoheptanoate

Base Information

• Chemical Name: ethyl (R)-7-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-7-oxoheptanoate
• CAS No.: 139688-08-7
• Molecular Formula: C₄₀H₅₃N₃O₅
• Molecular Weight: 655.878

Synonyms:ethyl (R)-7-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-7-oxoheptanoate

Chemical Property of ethyl (R)-7-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-7-oxoheptanoate

Chemical Property:

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Technology Process of ethyl (R)-7-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-7-oxoheptanoate

There total 3 articles about ethyl (R)-7-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.1^3,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-7-oxoheptanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 68.0%

ethyl 6-(chloroformyl)hexanoate (14794-32-2) + tricyclo<3.3.1.13,7>dec-2-yl <1-(1H-indol-3-ylmethyl)-1-methyl-2-<(2-phenylethyl)amino>ethyl>carbamate (139657-24-2) → ethyl (R)-7-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-7-oxoheptanoate (139688-08-7)

Guidance literature:

With triethylamine; In dichloromethane; at 0 ℃; for 0.333333h;

DOI:10.1021/jm00086a017

Reference yield:

7-ethoxy-7-oxoheptanoic acid (33018-91-6) → ethyl (R)-7-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-7-oxoheptanoate (139688-08-7)

Guidance literature:

Multi-step reaction with 2 steps

1: oxalyl chloride

2: 68 percent / triethylamine / CH₂Cl₂ / 0.33 h / 0 °C

With oxalyl dichloride; triethylamine; In dichloromethane;

DOI:10.1021/jm00086a017

Reference yield:

tricyclo[3.3.1.13,7]dec-2-yl (R)-{1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]ethyl}carbamate (130406-43-8) → ethyl (R)-7-<<3-(1H-indol-3-yl)-2-methyl-2-<<(tricyclo<3.3.1.13,7>dec-2-yloxy)carbonyl>amino>propyl>(2-phenylethyl)amino>-7-oxoheptanoate (139688-08-7)

Guidance literature:

Multi-step reaction with 2 steps

1: 14 percent / lithium borohydride, chlorotrimethylsilane / tetrahydrofuran / 20 h / Ambient temperature

2: 68 percent / triethylamine / CH₂Cl₂ / 0.33 h / 0 °C

With lithium borohydride; chloro-trimethyl-silane; triethylamine; In tetrahydrofuran; dichloromethane;

DOI:10.1021/jm00086a017

upstream raw materials:

ethyl 6-(chloroformyl)hexanoate

tricyclo<3.3.1.1^3,7>dec-2-yl <1-(1H-indol-3-ylmethyl)-1-methyl-2-<(2-phenylethyl)amino>ethyl>carbamate

7-ethoxy-7-oxoheptanoic acid

tricyclo[3.3.1.1^3,7]dec-2-yl (R)-{1-(1H-indol-3-ylmethyl)-1-methyl-2-oxo-2-[(2-phenylethyl)amino]ethyl}carbamate

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