cyclohexyl 2-diazo-3-oxobutanoate

Base Information

• Chemical Name: cyclohexyl 2-diazo-3-oxobutanoate
• CAS No.: 157944-16-6
• Molecular Formula: C₁₀H₁₄N₂O₃
• Molecular Weight: 210.233
• Mol file: 157944-16-6.mol

Synonyms:cyclohexyl 2-diazo-3-oxobutanoate

Chemical Property of cyclohexyl 2-diazo-3-oxobutanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of cyclohexyl 2-diazo-3-oxobutanoate

There total 3 articles about cyclohexyl 2-diazo-3-oxobutanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

cyclohexyl 3-oxobutanoate (6947-02-0) → cyclohexyl 2-diazo-3-oxobutanoate (157944-16-6)

Guidance literature:

With 4-toluenesulfonyl azide; triethylamine; In acetonitrile; at 20 ℃;

DOI:10.1016/j.tetlet.2014.03.115

Reference yield:

cyclohexanol (108-93-0) → cyclohexyl 2-diazo-3-oxobutanoate (157944-16-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / xylene / 0.5 h / Heating

2: 77 percent / methane sulfonyl azide, Et₃N / acetonitrile / 3 h / Ambient temperature

With triethylamine; Methanesulfonyl azide; In acetonitrile; xylene;

DOI:10.1002/hlca.19940770307

Reference yield:

cyclohexanol (108-93-0) → cyclohexyl 2-diazo-3-oxobutanoate (157944-16-6)

Guidance literature:

Multi-step reaction with 2 steps

1: sodium acetate / tetrahydrofuran / 2 h / Reflux

2: 4-toluenesulfonyl azide; triethylamine / acetonitrile / 20 °C

With 4-toluenesulfonyl azide; sodium acetate; triethylamine; In tetrahydrofuran; acetonitrile;

DOI:10.1016/j.tetlet.2014.03.115

upstream raw materials:

cyclohexyl 3-oxobutanoate

cyclohexanol

Downstream raw materials:

cyclohexyl diazoacetate

Refernces

• 1、 Sha, Qiang,Arman, Hadi,Doyle, Michael P.. "Asymmetric synthesis of 1H-pyrrol-3(2H)-ones from 2,3-diketoesters by combination of aldol condensation with benzilic acid rearrangement". supporting information. p. 108 - 111. Retrieved 2015/12/26.
• 2、 Mueller, Paul,Polleux, Philippe. "63. Enantioselective Formation of Bicyclic Lactones by Rhodium-Catalyzed Intramolecular CH-Insertion Reactions". . p. 645 - 654. Retrieved 2007/10/02.