2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-3-(4-hydroxymethyl-phenyl)-propionic acid 2,2,2-trichloro-ethyl ester

Base Information

Chemical Name:2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-3-(4-hydroxymethyl-phenyl)-propionic acid 2,2,2-trichloro-ethyl ester
CAS No.:1055303-75-7
Molecular Formula:C₂₀H₂₀Cl₃FO₃S
Molecular Weight:465.8
Hs Code.:

Synonyms:2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-3-(4-hydroxymethyl-phenyl)-propionic acid 2,2,2-trichloro-ethyl ester

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Chemical Property of 2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-3-(4-hydroxymethyl-phenyl)-propionic acid 2,2,2-trichloro-ethyl ester

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Technology Process of 2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-3-(4-hydroxymethyl-phenyl)-propionic acid 2,2,2-trichloro-ethyl ester

There total 7 articles about 2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-3-(4-hydroxymethyl-phenyl)-propionic acid 2,2,2-trichloro-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 82.5%

: 1055303-74-6
3-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-propionic acid 2,2,2-trichloro-ethyl ester

: 1055303-75-7
2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-3-(4-hydroxymethyl-phenyl)-propionic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: 3-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-propionic acid 2,2,2-trichloro-ethyl ester; With boron trifluoride diethyl etherate; In dichloromethane; at 0 ℃; for 0.5h;

With hydrogenchloride; water; In dichloromethane;

Reference yield:

: 1055303-71-3
3-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-2-chloro-propionic acid methyl ester

: 1055303-75-7
2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-3-(4-hydroxymethyl-phenyl)-propionic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 4 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 18 h / 0 °C

2.1: sodium hydroxide; water / tetrahydrofuran / 29 h / 0 - 20 °C

2.2: pH 2

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

4.1: boron trifluoride diethyl etherate / dichloromethane / 0.5 h / 0 °C

With dmap; sodium hydroxide; boron trifluoride diethyl etherate; water; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;

Reference yield:

: 455267-22-8
thioacetic acid S-[2-(4-fluoro-phenyl)-ethyl] ester

: 1055303-75-7
2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-3-(4-hydroxymethyl-phenyl)-propionic acid 2,2,2-trichloro-ethyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C

1.2: 0 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 18 h / 0 °C

3.1: sodium hydroxide; water / tetrahydrofuran / 29 h / 0 - 20 °C

3.2: pH 2

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

5.1: boron trifluoride diethyl etherate / dichloromethane / 0.5 h / 0 °C

With dmap; sodium hydroxide; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; water; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide;