4-[2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-2-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-benzoic acid

Base Information

Chemical Name:4-[2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-2-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-benzoic acid
CAS No.:1055303-80-4
Molecular Formula:C₂₀H₁₈Cl₃FO₄S
Molecular Weight:479.784
Hs Code.:

Synonyms:4-[2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-2-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-benzoic acid

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Chemical Property of 4-[2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-2-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-benzoic acid

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Technology Process of 4-[2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-2-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-benzoic acid

There total 8 articles about 4-[2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-2-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-benzoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.6%

: 1055303-75-7
2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-3-(4-hydroxymethyl-phenyl)-propionic acid 2,2,2-trichloro-ethyl ester

: 1055303-80-4
4-[2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-2-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-benzoic acid

Guidance literature:: 2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-3-(4-hydroxymethyl-phenyl)-propionic acid 2,2,2-trichloro-ethyl ester; With potassium permanganate; In acetone; for 18h;

With hydrogenchloride; water; In acetone;

Reference yield:

: 1055303-71-3
3-[4-(tert-butyl-dimethyl-silanyloxymethyl)-phenyl]-2-chloro-propionic acid methyl ester

: 1055303-80-4
4-[2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-2-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-benzoic acid

Guidance literature:: Multi-step reaction with 5 steps

1.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C

1.2: 18 h / 0 °C

2.1: sodium hydroxide; water / tetrahydrofuran / 29 h / 0 - 20 °C

2.2: pH 2

3.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

4.1: boron trifluoride diethyl etherate / dichloromethane / 0.5 h / 0 °C

5.1: potassium permanganate / acetone / 18 h

With dmap; sodium hydroxide; potassium permanganate; boron trifluoride diethyl etherate; water; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;

Reference yield:

: 455267-22-8
thioacetic acid S-[2-(4-fluoro-phenyl)-ethyl] ester

: 1055303-80-4
4-[2-[2-(4-fluoro-phenyl)-ethylsulfanyl]-2-(2,2,2-trichloro-ethoxycarbonyl)-ethyl]-benzoic acid

Guidance literature:: Multi-step reaction with 6 steps

1.1: lithium aluminium tetrahydride / tetrahydrofuran / 2 h / 20 °C

1.2: 0 °C

2.1: caesium carbonate / N,N-dimethyl-formamide / 0.5 h / 0 °C

2.2: 18 h / 0 °C

3.1: sodium hydroxide; water / tetrahydrofuran / 29 h / 0 - 20 °C

3.2: pH 2

4.1: dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride / dichloromethane / 0 - 20 °C

5.1: boron trifluoride diethyl etherate / dichloromethane / 0.5 h / 0 °C

6.1: potassium permanganate / acetone / 18 h

With dmap; sodium hydroxide; potassium permanganate; lithium aluminium tetrahydride; boron trifluoride diethyl etherate; water; caesium carbonate; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; N,N-dimethyl-formamide; acetone;