Technology Process of (3S,4S)-4-(benzyloxy)-1-(tert-butyldiphenylsilyloxy)oct-7-en-3-ol
There total 9 articles about (3S,4S)-4-(benzyloxy)-1-(tert-butyldiphenylsilyloxy)oct-7-en-3-ol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
((3S,4S)-4-(benzyloxy)-3-(4-methoxybenzyloxy)oct-7-enyloxy)(tert-butyl)diphenylsilane;
With
water; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
dichloromethane;
at 20 ℃;
for 1h;
With
sodium hydrogencarbonate;
In
dichloromethane; water;
DOI:10.1016/j.tetasy.2012.02.009
- Guidance literature:
-
Multi-step reaction with 10 steps
1.1: sodium hydride / tetrahydrofuran; paraffin oil / 0 °C
1.2: 6 h / 20 °C
2.1: ozone / dichloromethane / 0.25 h / -78 °C
2.2: -78 °C
3.1: sodium tetrahydroborate / methanol / 0 - 20 °C
4.1: 1H-imidazole / dichloromethane / 0 - 20 °C
5.1: copper(II) choride dihydrate / acetonitrile / 0 - 20 °C
6.1: di(n-butyl)tin oxide; triethylamine / dichloromethane / 0.5 h / 20 °C
7.1: potassium carbonate / methanol / 1 h / 20 °C
8.1: magnesium / diethyl ether
8.2: 2 h / -40 - 20 °C
9.1: sodium hydride / tetrahydrofuran; paraffin oil / 0.5 h / 0 °C
9.2: 5 h / 20 °C
10.1: water; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1 h / 20 °C
With
1H-imidazole; sodium tetrahydroborate; copper(II) choride dihydrate; water; sodium hydride; di(n-butyl)tin oxide; potassium carbonate; ozone; magnesium; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetonitrile; paraffin oil;
DOI:10.1016/j.tetasy.2012.02.009
- Guidance literature:
-
Multi-step reaction with 9 steps
1.1: ozone / dichloromethane / 0.25 h / -78 °C
1.2: -78 °C
2.1: sodium tetrahydroborate / methanol / 0 - 20 °C
3.1: 1H-imidazole / dichloromethane / 0 - 20 °C
4.1: copper(II) choride dihydrate / acetonitrile / 0 - 20 °C
5.1: di(n-butyl)tin oxide; triethylamine / dichloromethane / 0.5 h / 20 °C
6.1: potassium carbonate / methanol / 1 h / 20 °C
7.1: magnesium / diethyl ether
7.2: 2 h / -40 - 20 °C
8.1: sodium hydride / tetrahydrofuran; paraffin oil / 0.5 h / 0 °C
8.2: 5 h / 20 °C
9.1: water; 2,3-dicyano-5,6-dichloro-p-benzoquinone / dichloromethane / 1 h / 20 °C
With
1H-imidazole; sodium tetrahydroborate; copper(II) choride dihydrate; water; sodium hydride; di(n-butyl)tin oxide; potassium carbonate; ozone; magnesium; triethylamine; 2,3-dicyano-5,6-dichloro-p-benzoquinone;
In
tetrahydrofuran; methanol; diethyl ether; dichloromethane; acetonitrile; paraffin oil;
DOI:10.1016/j.tetasy.2012.02.009
