phenyl-[1-(4-trifluoromethyl-phenylethynyl)-1H-imidazol-2-yl]-methanol

Base Information

• Chemical Name: phenyl-[1-(4-trifluoromethyl-phenylethynyl)-1H-imidazol-2-yl]-methanol
• CAS No.: 1197210-82-4
• Molecular Formula: C₁₉H₁₃F₃N₂O
• Molecular Weight: 342.32
• Mol file: 1197210-82-4.mol

Synonyms:phenyl-[1-(4-trifluoromethyl-phenylethynyl)-1H-imidazol-2-yl]-methanol

Chemical Property of phenyl-[1-(4-trifluoromethyl-phenylethynyl)-1H-imidazol-2-yl]-methanol

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of phenyl-[1-(4-trifluoromethyl-phenylethynyl)-1H-imidazol-2-yl]-methanol

There total 1 articles about phenyl-[1-(4-trifluoromethyl-phenylethynyl)-1H-imidazol-2-yl]-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

1-(4-trifluoromethyl-phenylethynyl)-1H-imidazole (1197210-73-3) + benzaldehyde (100-52-7) → phenyl-[1-(4-trifluoromethyl-phenylethynyl)-1H-imidazol-2-yl]-methanol (1197210-82-4)

Guidance literature:

1-(4-trifluoromethyl-phenylethynyl)-1H-imidazole; With n-butyllithium; In tetrahydrofuran; hexane; at -78 ℃; for 0.25h; Inert atmosphere;

benzaldehyde; In tetrahydrofuran; hexane; at -78 ℃; for 0.5h; Inert atmosphere;

With hydrogenchloride; In tetrahydrofuran; hexane; water; at -78 - 20 ℃; Inert atmosphere;

DOI:10.1021/jo902073m

Reference yield: 85.0%

phenyl-[1-(4-trifluoromethyl-phenylethynyl)-1H-imidazol-2-yl]-methanol (1197210-82-4) → (Z)-7-phenyl-5-(4-(trifluoromethyl)benzylidene)-5,7-dihydroimidazo[1,2-c]oxazole (1197210-94-8)

Guidance literature:

With potassium phosphate; In acetonitrile; Inert atmosphere; Reflux;

DOI:10.1021/jo902073m

Reference yield: 85.0%

phenyl-[1-(4-trifluoromethyl-phenylethynyl)-1H-imidazol-2-yl]-methanol (1197210-82-4) → 8-phenyl-6-(4-(trifluoromethyl)phenyl)-8H-imidazo[2,1-c][1,4]oxazine (1197211-04-3)

Guidance literature:

With gold(III) chloride; In acetonitrile; Inert atmosphere; Reflux;

DOI:10.1021/jo902073m

upstream raw materials:

1-(4-trifluoromethyl-phenylethynyl)-1H-imidazole

benzaldehyde

Downstream raw materials:

(Z)-7-phenyl-5-(4-(trifluoromethyl)benzylidene)-5,7-dihydroimidazo[1,2-c]oxazole

8-phenyl-6-(4-(trifluoromethyl)phenyl)-8H-imidazo[2,1-c][1,4]oxazine